1-[(3R,4S)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(3-fluoro-phenyl)-pyrrolidin-1-ylmethyl]-cyclohexanecarboxylic acid benzyl ester

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Chemical Name:1-[(3R,4S)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(3-fluoro-phenyl)-pyrrolidin-1-ylmethyl]-cyclohexanecarboxylic acid benzyl ester
CAS No.:419572-32-0
Molecular Formula:C₃₂H₄₆FNO₃Si
Molecular Weight:539.806
Hs Code.:

Synonyms:1-[(3R,4S)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(3-fluoro-phenyl)-pyrrolidin-1-ylmethyl]-cyclohexanecarboxylic acid benzyl ester

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Chemical Property of 1-[(3R,4S)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(3-fluoro-phenyl)-pyrrolidin-1-ylmethyl]-cyclohexanecarboxylic acid benzyl ester

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Technology Process of 1-[(3R,4S)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(3-fluoro-phenyl)-pyrrolidin-1-ylmethyl]-cyclohexanecarboxylic acid benzyl ester

There total 3 articles about 1-[(3R,4S)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(3-fluoro-phenyl)-pyrrolidin-1-ylmethyl]-cyclohexanecarboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15014-25-2
malonic acid dibenzyl ester

: 419572-32-0
1-[(3R,4S)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(3-fluoro-phenyl)-pyrrolidin-1-ylmethyl]-cyclohexanecarboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: K₂CO₃ / dimethylsulfoxide

2: DIBAL / CH₂Cl₂ / -78 °C

3: NaB(OAc)3H / CH₂Cl₂

With sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; potassium carbonate; In dichloromethane; dimethyl sulfoxide;
DOI:10.1021/ol034707c

Reference yield:

: 208662-21-9
dibenzyl cyclohexane-1,1-dicarboxylate

: 419572-32-0
1-[(3R,4S)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-4-(3-fluoro-phenyl)-pyrrolidin-1-ylmethyl]-cyclohexanecarboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: DIBAL / CH₂Cl₂ / -78 °C

2: NaB(OAc)3H / CH₂Cl₂

With sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; In dichloromethane;
DOI:10.1021/ol034707c