tert-butyl 3-(isoquinolin-6-ylamino)-3-oxo-2-(4-(triisopropylsilyloxy)phenyl)propylcarbamate

Base Information

Chemical Name:tert-butyl 3-(isoquinolin-6-ylamino)-3-oxo-2-(4-(triisopropylsilyloxy)phenyl)propylcarbamate
CAS No.:1253955-03-1
Molecular Formula:C₃₂H₄₅N₃O₄Si
Molecular Weight:563.812
Hs Code.:

Synonyms:tert-butyl 3-(isoquinolin-6-ylamino)-3-oxo-2-(4-(triisopropylsilyloxy)phenyl)propylcarbamate

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Chemical Property of tert-butyl 3-(isoquinolin-6-ylamino)-3-oxo-2-(4-(triisopropylsilyloxy)phenyl)propylcarbamate

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Technology Process of tert-butyl 3-(isoquinolin-6-ylamino)-3-oxo-2-(4-(triisopropylsilyloxy)phenyl)propylcarbamate

There total 7 articles about tert-butyl 3-(isoquinolin-6-ylamino)-3-oxo-2-(4-(triisopropylsilyloxy)phenyl)propylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1253955-02-0
3-amino-N-(isoquinolin-6-yl)-2-(4-(triisopropylsilyloxy)phenyl)propanamide

: 1253955-03-1
tert-butyl 3-(isoquinolin-6-ylamino)-3-oxo-2-(4-(triisopropylsilyloxy)phenyl)propylcarbamate

Guidance literature:: In dichloromethane; at 0 ℃;

Reference yield: 70.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1253955-01-9
3-(1,3-dioxoisoindolin-2-yl)-N-(isoquinolin-6-yl)-2-(4-(triisopropylsilyloxy)phenyl)propanamide

: 1253955-03-1
tert-butyl 3-(isoquinolin-6-ylamino)-3-oxo-2-(4-(triisopropylsilyloxy)phenyl)propylcarbamate

Guidance literature:: 3-(1,3-dioxoisoindolin-2-yl)-N-(isoquinolin-6-yl)-2-(4-(triisopropylsilyloxy)phenyl)propanamide; With hydrazine; In methanol; Reflux;

di-tert-butyl dicarbonate; With triethylamine; In dichloromethane;
DOI:10.1016/j.bmcl.2016.03.104

Reference yield:

: 1253954-99-2
methyl 3-(1,3-dioxoisoindolin-2-yl)-2-(4-(triisopropylsilyloxy)phenyl)propanoate

: 1253955-03-1
tert-butyl 3-(isoquinolin-6-ylamino)-3-oxo-2-(4-(triisopropylsilyloxy)phenyl)propylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide monohydrate / tetrahydrofuran; water

2: 1,2-dichloro-ethane; dmap

3: hydrazine / methanol / Reflux

With dmap; lithium hydroxide monohydrate; 1,2-dichloro-ethane; hydrazine; In tetrahydrofuran; methanol; water;
DOI:10.1016/j.bmcl.2016.03.104