3-(1,3-dioxoisoindolin-2-yl)-N-(isoquinolin-6-yl)-2-(4-(triisopropylsilyloxy)phenyl)propanamide

Base Information

Chemical Name:3-(1,3-dioxoisoindolin-2-yl)-N-(isoquinolin-6-yl)-2-(4-(triisopropylsilyloxy)phenyl)propanamide
CAS No.:1253955-01-9
Molecular Formula:C₃₅H₃₉N₃O₄Si
Molecular Weight:593.798
Hs Code.:

Synonyms:3-(1,3-dioxoisoindolin-2-yl)-N-(isoquinolin-6-yl)-2-(4-(triisopropylsilyloxy)phenyl)propanamide

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Chemical Property of 3-(1,3-dioxoisoindolin-2-yl)-N-(isoquinolin-6-yl)-2-(4-(triisopropylsilyloxy)phenyl)propanamide

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Technology Process of 3-(1,3-dioxoisoindolin-2-yl)-N-(isoquinolin-6-yl)-2-(4-(triisopropylsilyloxy)phenyl)propanamide

There total 5 articles about 3-(1,3-dioxoisoindolin-2-yl)-N-(isoquinolin-6-yl)-2-(4-(triisopropylsilyloxy)phenyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 23687-26-5
6-isoquinolinamine

: 1253955-00-8
2-(2-carboxy-2-(4-(triisopropylsilyloxy)phenyl)ethylcarbamoyl)benzoic acid

: 1253955-01-9
3-(1,3-dioxoisoindolin-2-yl)-N-(isoquinolin-6-yl)-2-(4-(triisopropylsilyloxy)phenyl)propanamide

Guidance literature:: 2-(2-carboxy-2-(4-(triisopropylsilyloxy)phenyl)ethylcarbamoyl)benzoic acid; With dmap; 1,2-dichloro-ethane;

6-isoquinolinamine;
DOI:10.1016/j.bmcl.2016.03.104

Reference yield:

: 14199-15-6
Methyl 4-hydroxyphenylacetate

: 1253955-01-9
3-(1,3-dioxoisoindolin-2-yl)-N-(isoquinolin-6-yl)-2-(4-(triisopropylsilyloxy)phenyl)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1: 2,6-dimethylpyridine / dichloromethane

2: lithium hexamethyldisilazane / tetrahydrofuran / -78 - 0 °C

3: lithium hydroxide monohydrate / tetrahydrofuran; water

4: 1,2-dichloro-ethane; dmap

With 2,6-dimethylpyridine; dmap; lithium hydroxide monohydrate; 1,2-dichloro-ethane; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.bmcl.2016.03.104

Reference yield:

: 243641-04-5
methyl 2-(4-(triisopropylsilyloxy)phenyl)acetate

: 1253955-01-9
3-(1,3-dioxoisoindolin-2-yl)-N-(isoquinolin-6-yl)-2-(4-(triisopropylsilyloxy)phenyl)propanamide

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / -78 - 0 °C

2: lithium hydroxide monohydrate / tetrahydrofuran; water

3: 1,2-dichloro-ethane; dmap

With dmap; lithium hydroxide monohydrate; 1,2-dichloro-ethane; lithium hexamethyldisilazane; In tetrahydrofuran; water;
DOI:10.1016/j.bmcl.2016.03.104