1-[(1-tert-Butoxycarbonylamino-cyclohexanecarbonyl)-amino]-cyclohexanecarboxylic acid methyl ester

Base Information

Chemical Name:1-[(1-tert-Butoxycarbonylamino-cyclohexanecarbonyl)-amino]-cyclohexanecarboxylic acid methyl ester
CAS No.:174077-39-5
Molecular Formula:C₂₀H₃₄N₂O₅
Molecular Weight:382.5
Hs Code.:

Synonyms:1-[(1-tert-Butoxycarbonylamino-cyclohexanecarbonyl)-amino]-cyclohexanecarboxylic acid methyl ester

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Chemical Property of 1-[(1-tert-Butoxycarbonylamino-cyclohexanecarbonyl)-amino]-cyclohexanecarboxylic acid methyl ester

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Technology Process of 1-[(1-tert-Butoxycarbonylamino-cyclohexanecarbonyl)-amino]-cyclohexanecarboxylic acid methyl ester

There total 4 articles about 1-[(1-tert-Butoxycarbonylamino-cyclohexanecarbonyl)-amino]-cyclohexanecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 115951-16-1
1-tert-butoxycarbonylaminocyclohexanecarboxylic acid

: 37993-32-1
1-amino-cyclohexanecarboxylic acid methyl ester hydrochloride

: 174077-39-5
1-[(1-tert-Butoxycarbonylamino-cyclohexanecarbonyl)-amino]-cyclohexanecarboxylic acid methyl ester

Guidance literature:: With TEA; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 13h;
DOI:10.1021/jm950490j

Reference yield:

: 2756-85-6
1-aminocyclohexane carboxylic acid

: 174077-39-5
1-[(1-tert-Butoxycarbonylamino-cyclohexanecarbonyl)-amino]-cyclohexanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: HCl / 4 h / Heating

2: 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide hydrochloride, 1-hydroxybenzotriazole / CH₂Cl₂ / 24 h / Ambient temperature

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1021/ja962905b

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 174077-39-5
1-[(1-tert-Butoxycarbonylamino-cyclohexanecarbonyl)-amino]-cyclohexanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: aq. NaOH / dioxane / 12 h / Ambient temperature

2: 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide hydrochloride, 1-hydroxybenzotriazole / CH₂Cl₂ / 24 h / Ambient temperature

With sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; dichloromethane;
DOI:10.1021/ja962905b