(2R,5R,6S)-6-benzoyloxy-2-(tert-butyl)-5-methoxycarbonyl-8-oxo-3-oxa-1-azabicyclo[3.3.0]octane

Base Information

Chemical Name:(2R,5R,6S)-6-benzoyloxy-2-(tert-butyl)-5-methoxycarbonyl-8-oxo-3-oxa-1-azabicyclo[3.3.0]octane
CAS No.:418763-22-1
Molecular Formula:C₁₉H₂₃NO₆
Molecular Weight:361.395
Hs Code.:

Synonyms:(2R,5R,6S)-6-benzoyloxy-2-(tert-butyl)-5-methoxycarbonyl-8-oxo-3-oxa-1-azabicyclo[3.3.0]octane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,5R,6S)-6-benzoyloxy-2-(tert-butyl)-5-methoxycarbonyl-8-oxo-3-oxa-1-azabicyclo[3.3.0]octane

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Technology Process of (2R,5R,6S)-6-benzoyloxy-2-(tert-butyl)-5-methoxycarbonyl-8-oxo-3-oxa-1-azabicyclo[3.3.0]octane

There total 1 articles about (2R,5R,6S)-6-benzoyloxy-2-(tert-butyl)-5-methoxycarbonyl-8-oxo-3-oxa-1-azabicyclo[3.3.0]octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98-88-4
benzoyl chloride

: 418763-17-4
(2R,5R,6S)-1-aza-2-(tert-butyl)-6-hydroxy-5-methoxycarbonyl-3-oxa-8-oxobicyclo[3.3.0]octane

: 418763-22-1
(2R,5R,6S)-6-benzoyloxy-2-(tert-butyl)-5-methoxycarbonyl-8-oxo-3-oxa-1-azabicyclo[3.3.0]octane

Guidance literature:: With pyridine; In dichloromethane; for 24h; Heating;
DOI:10.1039/b108056n

Reference yield: 97.0%

: 418763-22-1
(2R,5R,6S)-6-benzoyloxy-2-(tert-butyl)-5-methoxycarbonyl-8-oxo-3-oxa-1-azabicyclo[3.3.0]octane

: 418763-23-2
(2R,3S)-6-benzoyloxy-2-hydroxymethyl-2-methoxycarbonylpyrrolidin-5-one

Guidance literature:: With 1.3-propanedithiol; hydrogenchloride; 2,2,2-trifluoroethanol; at 20 ℃; for 22h;
DOI:10.1039/b108056n

Reference yield:

: 418763-22-1
(2R,5R,6S)-6-benzoyloxy-2-(tert-butyl)-5-methoxycarbonyl-8-oxo-3-oxa-1-azabicyclo[3.3.0]octane

: (2R,3S)-6-benzoyloxy-2-tert-butoxycarbonyloxymethyl-2-methoxycarbonylpyrrolidin-5-one

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / CF₃CH₂OH; HS(CH₂)3SH; HCl / 22 h / 20 °C

2: 31 percent / ET₃N; DMAP / CH₂Cl₂ / 5 h / 20 °C

With 1.3-propanedithiol; hydrogenchloride; dmap; 2,2,2-trifluoroethanol; triethylamine; In dichloromethane;
DOI:10.1039/b108056n