(E)-N-(2-(5-bromo-1H-indol-3-yl)ethyl)-4-methyl-N-(4-oxopent-2-en-1-yl)benzenesulfonamide

Base Information

Chemical Name:(E)-N-(2-(5-bromo-1H-indol-3-yl)ethyl)-4-methyl-N-(4-oxopent-2-en-1-yl)benzenesulfonamide
CAS No.:1334535-09-9
Molecular Formula:C₂₂H₂₃BrN₂O₃S
Molecular Weight:475.406
Hs Code.:

Synonyms:(E)-N-(2-(5-bromo-1H-indol-3-yl)ethyl)-4-methyl-N-(4-oxopent-2-en-1-yl)benzenesulfonamide

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Chemical Property of (E)-N-(2-(5-bromo-1H-indol-3-yl)ethyl)-4-methyl-N-(4-oxopent-2-en-1-yl)benzenesulfonamide

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Technology Process of (E)-N-(2-(5-bromo-1H-indol-3-yl)ethyl)-4-methyl-N-(4-oxopent-2-en-1-yl)benzenesulfonamide

There total 2 articles about (E)-N-(2-(5-bromo-1H-indol-3-yl)ethyl)-4-methyl-N-(4-oxopent-2-en-1-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1334535-04-4
C₂₀H₂₁BrN₂O₂S

: 78-94-4,25038-87-3
methyl vinyl ketone

: 1334535-09-9
(E)-N-(2-(5-bromo-1H-indol-3-yl)ethyl)-4-methyl-N-(4-oxopent-2-en-1-yl)benzenesulfonamide

Guidance literature:: With 1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene[2-(iso-propoxy)-5-(N,N-dimethylaminosulfonyl)phenyl]methylene ruthenium(II) dichloride; In 1,2-dichloro-ethane; at 60 ℃; for 48h; optical yield given as %de; Inert atmosphere;
DOI:10.1002/anie.201103937

Reference yield:

: 1334535-00-0
N-(2-(5-bromo-1H-indol-3-yl)ethyl)-4-methylbenzenesulfonamide

: 1334535-09-9
(E)-N-(2-(5-bromo-1H-indol-3-yl)ethyl)-4-methyl-N-(4-oxopent-2-en-1-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / water; acetic acid / Inert atmosphere

2: 1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene[2-(iso-propoxy)-5-(N,N-dimethylaminosulfonyl)phenyl]methylene ruthenium(II) dichloride / 1,2-dichloro-ethane / 48 h / 60 °C / Inert atmosphere

With 1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene[2-(iso-propoxy)-5-(N,N-dimethylaminosulfonyl)phenyl]methylene ruthenium(II) dichloride; sodium hydroxide; In water; acetic acid; 1,2-dichloro-ethane;
DOI:10.1002/anie.201103937

Reference yield: 72.0%

: 1334535-09-9
(E)-N-(2-(5-bromo-1H-indol-3-yl)ethyl)-4-methyl-N-(4-oxopent-2-en-1-yl)benzenesulfonamide

: C₂₂H₂₃BrN₂O₃S

: 1334535-25-9
(4aR,7aR,12bR)-11-bromo-3-tosyl-1,2,3,4,4a,5,7a,8-octahydropyrido[3,4-d]carbazol-6(7H)-one

Guidance literature:: With 9-epi-9-amino-9-deoxyquinine; ortho-nitrobenzoic acid; In ethyl acetate; at 20 ℃; for 21h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1002/anie.201103937