4-(5-chloro-2-methoxyphenyl)-5-[4-(trifluoromethyl)-phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-thione

Base Information

Chemical Name:4-(5-chloro-2-methoxyphenyl)-5-[4-(trifluoromethyl)-phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-thione
CAS No.:202822-51-3
Molecular Formula:C₁₆H₁₁ClF₃N₃OS
Molecular Weight:385.797
Hs Code.:

Synonyms:4-(5-chloro-2-methoxyphenyl)-5-[4-(trifluoromethyl)-phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-thione

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Chemical Property of 4-(5-chloro-2-methoxyphenyl)-5-[4-(trifluoromethyl)-phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-thione

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Technology Process of 4-(5-chloro-2-methoxyphenyl)-5-[4-(trifluoromethyl)-phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-thione

There total 6 articles about 4-(5-chloro-2-methoxyphenyl)-5-[4-(trifluoromethyl)-phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 6160-65-2
1,1'-Thiocarbonyldiimidazole

: 202822-42-2
N-(5-chloro-2-methoxyphenyl)-4-(trifluoromethyl)benzene carbohydrazonamide

: 202822-51-3
4-(5-chloro-2-methoxyphenyl)-5-[4-(trifluoromethyl)-phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-thione

Guidance literature:: In tetrahydrofuran; for 18h; Heating;
DOI:10.1021/jm010569q

Reference yield:

: 202822-42-2
N-(5-chloro-2-methoxyphenyl)-4-(trifluoromethyl)benzene carbohydrazonamide

: 202822-51-3
4-(5-chloro-2-methoxyphenyl)-5-[4-(trifluoromethyl)-phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-thione

Guidance literature:: In tetrahydrofuran; ethyl acetate;

Reference yield:

: 329-15-7
4-trifluoromethyl-phenyl acetyl chloride

: 202822-51-3
4-(5-chloro-2-methoxyphenyl)-5-[4-(trifluoromethyl)-phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-thione

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / tetrahydrofuran / 18 h / 24 °C

2: PCl₅ / benzene / 3 h / Heating

3: hydrazine / tetrahydrofuran / 1 h / 24 °C

4: 68 percent / tetrahydrofuran / 18 h / Heating

With phosphorus pentachloride; triethylamine; hydrazine; In tetrahydrofuran; benzene;
DOI:10.1021/jm010569q