4-[2-cyclohexyl-2-(2-methylamino-propionylamino)-acetyl]-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester

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Chemical Name:4-[2-cyclohexyl-2-(2-methylamino-propionylamino)-acetyl]-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester
CAS No.:1218931-19-1
Molecular Formula:C₂₆H₃₈N₄O₄
Molecular Weight:470.612
Hs Code.:

Synonyms:4-[2-cyclohexyl-2-(2-methylamino-propionylamino)-acetyl]-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester

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Chemical Property of 4-[2-cyclohexyl-2-(2-methylamino-propionylamino)-acetyl]-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester

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Technology Process of 4-[2-cyclohexyl-2-(2-methylamino-propionylamino)-acetyl]-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester

There total 13 articles about 4-[2-cyclohexyl-2-(2-methylamino-propionylamino)-acetyl]-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1218931-28-2
4-{2-[2-(tert-butoxycarbonyl-methyl-amino)-propionylamino]-2-cyclohexyl-acetyl}-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester

: 1218931-19-1
4-[2-cyclohexyl-2-(2-methylamino-propionylamino)-acetyl]-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester

Guidance literature:: 4-{2-[2-(tert-butoxycarbonyl-methyl-amino)-propionylamino]-2-cyclohexyl-acetyl}-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester; With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 2.75h;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

: 757247-71-5
tert-butyl (2S,3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-2-formylpyrrolidine-1-carboxylate

: 1218931-19-1
4-[2-cyclohexyl-2-(2-methylamino-propionylamino)-acetyl]-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: triethylamine / 12 h

1.2: 1 h / -78 °C

1.3: 1 h / -78 °C

2.1: sodium tetrahydroborate; water / tetrahydrofuran / 2 h / 20 °C

3.1: hydrogen / ethanol; water / 2 h / 2844.39 Torr

3.2: 16 h / 0 - 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 0 - 20 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C

7.1: trifluoroacetic acid / dichloromethane / 2.5 h / 0 °C

7.3: 16 h / 0 - 20 °C

8.1: trifluoroacetic acid / dichloromethane / 1.25 h / 0 °C

8.3: 16 h / 0 - 20 °C

9.1: trifluoroacetic acid / dichloromethane / 2.75 h / 0 °C

With sodium tetrahydroborate; tetrabutyl ammonium fluoride; water; hydrogen; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 184046-78-4
(2S,3S)-1-tert-butyl-2-methyl 3-hydroxypyrrolidine-1,2-dicarboxylate

: 1218931-19-1
4-[2-cyclohexyl-2-(2-methylamino-propionylamino)-acetyl]-hexahydro-pyrrolo[3,2-b]pyrrole-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 12 steps

1.1: 1H-imidazole / dichloromethane / 6 h / 0 - 20 °C

2.1: lithium borohydride / tetrahydrofuran / 0 - 20 °C

3.1: pyridine-SO₃ complex; triethylamine / dichloromethane; dimethyl sulfoxide / 2 h / 0 - 20 °C

4.1: triethylamine / 12 h

4.2: 1 h / -78 °C

4.3: 1 h / -78 °C

5.1: sodium tetrahydroborate; water / tetrahydrofuran / 2 h / 20 °C

6.1: hydrogen / ethanol; water / 2 h / 2844.39 Torr

6.2: 16 h / 0 - 20 °C

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 0 - 20 °C

8.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C

9.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C

10.1: trifluoroacetic acid / dichloromethane / 2.5 h / 0 °C

10.3: 16 h / 0 - 20 °C

11.1: trifluoroacetic acid / dichloromethane / 1.25 h / 0 °C

11.3: 16 h / 0 - 20 °C

12.1: trifluoroacetic acid / dichloromethane / 2.75 h / 0 °C

With 1H-imidazole; sodium tetrahydroborate; lithium borohydride; pyridine-SO₃ complex; tetrabutyl ammonium fluoride; water; hydrogen; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;