hexahydro-pyrrolo[3,2-b]pyrrole-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester

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Chemical Name:hexahydro-pyrrolo[3,2-b]pyrrole-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester
CAS No.:1218931-25-9
Molecular Formula:C₁₉H₂₆N₂O₄
Molecular Weight:346.426
Hs Code.:

Synonyms:hexahydro-pyrrolo[3,2-b]pyrrole-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester

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Chemical Property of hexahydro-pyrrolo[3,2-b]pyrrole-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester

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Technology Process of hexahydro-pyrrolo[3,2-b]pyrrole-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester

There total 9 articles about hexahydro-pyrrolo[3,2-b]pyrrole-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1218931-24-8
2-(2-benzyloxycarbonylamino-ethyl)-3-methanesulfonyloxy-pyrrolidine-1-carboxylic acid tert-butyl ester

: 1218931-25-9
hexahydro-pyrrolo[3,2-b]pyrrole-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.166667h;

Reference yield:

: 757247-71-5
tert-butyl (2S,3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-2-formylpyrrolidine-1-carboxylate

: 1218931-25-9
hexahydro-pyrrolo[3,2-b]pyrrole-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / 12 h

1.2: 1 h / -78 °C

1.3: 1 h / -78 °C

2.1: sodium tetrahydroborate; water / tetrahydrofuran / 2 h / 20 °C

3.1: hydrogen / ethanol; water / 2 h / 2844.39 Torr

3.2: 16 h / 0 - 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 0 - 20 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C

With sodium tetrahydroborate; tetrabutyl ammonium fluoride; water; hydrogen; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1218929-35-1
(3S)-(tert-butyl-dimethyl-silanyloxy)-(2R)-(2-nitro-vinyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

: 1218931-25-9
hexahydro-pyrrolo[3,2-b]pyrrole-1,4-dicarboxylic acid 1-benzyl ester 4-tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate; water / tetrahydrofuran / 2 h / 20 °C

2.1: hydrogen / ethanol; water / 2 h / 2844.39 Torr

2.2: 16 h / 0 - 20 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 0 - 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C

With sodium tetrahydroborate; tetrabutyl ammonium fluoride; water; hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;