tert-butyl α-<(3S^,6S^)-3-amino-2-oxo-6-phenylperhydroazepin-1-yl>acetate

Base Information

Chemical Name:tert-butyl α-<(3S^*,6S^*)-3-amino-2-oxo-6-phenylperhydroazepin-1-yl>acetate
CAS No.:111743-12-5
Molecular Formula:C₁₈H₂₆N₂O₃
Molecular Weight:318.416
Hs Code.:

tert-butyl α-<(3S<sup>*</sup>,6S<sup>*</sup>)-3-amino-2-oxo-6-phenylperhydroazepin-1-yl>acetate

Synonyms:tert-butyl α-<(3S^*,6S^*)-3-amino-2-oxo-6-phenylperhydroazepin-1-yl>acetate

Suppliers and Price of tert-butyl α-<(3S^*,6S^*)-3-amino-2-oxo-6-phenylperhydroazepin-1-yl>acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl α-<(3S^*,6S^*)-3-amino-2-oxo-6-phenylperhydroazepin-1-yl>acetate

Chemical Property:

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Technology Process of tert-butyl α-<(3S^*,6S^*)-3-amino-2-oxo-6-phenylperhydroazepin-1-yl>acetate

There total 10 articles about tert-butyl α-<(3S^*,6S^*)-3-amino-2-oxo-6-phenylperhydroazepin-1-yl>acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: tert-butyl α-<(3S^*,6S^*)-3-azido-2-oxo-6-phenylperhydroazepin-1-yl>acetate

: 111743-12-5
tert-butyl α-<(3S^*,6S^*)-3-amino-2-oxo-6-phenylperhydroazepin-1-yl>acetate

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; Yield given;
DOI:10.1021/jm00397a027

Reference yield:

: 112093-43-3
Phenyl-6 tetrahydro-4,5,6,7 <3H>azepinone-2

: 111743-12-5
tert-butyl α-<(3S^*,6S^*)-3-amino-2-oxo-6-phenylperhydroazepin-1-yl>acetate

Guidance literature:: Multi-step reaction with 4 steps

1: 63 percent / PCl₅, I₂, Br₂ / CH₂Cl₂ / 1.5 h / Ambient temperature

2: 25 percent / NaN₃ / dimethylformamide / 4 h / 60 °C

3: NaH / dimethylformamide; paraffin

4: H₂ / Pd-C / ethanol

With sodium azide; phosphorus pentachloride; hydrogen; bromine; iodine; sodium hydride; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide; paraffin;
DOI:10.1021/jm00397a027

Reference yield:

: 140-29-4
phenylacetonitrile

: 111743-12-5
tert-butyl α-<(3S^*,6S^*)-3-amino-2-oxo-6-phenylperhydroazepin-1-yl>acetate

Guidance literature:: Multi-step reaction with 11 steps

1: 58 percent / NaH / dimethylformamide; paraffin / 4 h / Ambient temperature

2: H₂ / Raney-Ni / ethanol / 2.5 h / 40 °C

3: 30 percent / Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

4: aq. NaOH / ethanol / 1 h / Ambient temperature

5: 87 percent / DCC / CH₂Cl₂ / Ambient temperature

6: 95 percent / 4N HCl / dioxane / 1.5 h / Ambient temperature

7: 78 percent / Et₃N / CH₂Cl₂ / Ambient temperature

8: 63 percent / PCl₅, I₂, Br₂ / CH₂Cl₂ / 1.5 h / Ambient temperature

9: 25 percent / NaN₃ / dimethylformamide / 4 h / 60 °C

10: NaH / dimethylformamide; paraffin

11: H₂ / Pd-C / ethanol

With hydrogenchloride; sodium hydroxide; sodium azide; phosphorus pentachloride; hydrogen; bromine; iodine; sodium hydride; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; nickel; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; paraffin;
DOI:10.1021/jm00397a027