3,4,5-tri-O-benzyl-1,7-dideoxy-1,7-difluoro-D-glycero-α-D-lyxo-hept-2-ulopyranose

Base Information

Chemical Name:3,4,5-tri-O-benzyl-1,7-dideoxy-1,7-difluoro-D-glycero-α-D-lyxo-hept-2-ulopyranose
CAS No.:1357098-67-9
Molecular Formula:C₂₈H₃₀F₂O₅
Molecular Weight:484.54
Hs Code.:

Synonyms:3,4,5-tri-O-benzyl-1,7-dideoxy-1,7-difluoro-D-glycero-α-D-lyxo-hept-2-ulopyranose

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Chemical Property of 3,4,5-tri-O-benzyl-1,7-dideoxy-1,7-difluoro-D-glycero-α-D-lyxo-hept-2-ulopyranose

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Technology Process of 3,4,5-tri-O-benzyl-1,7-dideoxy-1,7-difluoro-D-glycero-α-D-lyxo-hept-2-ulopyranose

There total 10 articles about 3,4,5-tri-O-benzyl-1,7-dideoxy-1,7-difluoro-D-glycero-α-D-lyxo-hept-2-ulopyranose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1357098-64-6
3,4,5-tri-O-benzyl-2,6-anhydro-1,7-dideoxy-7-fluoro-D-mannohept-1-enitol

: 1357098-67-9
3,4,5-tri-O-benzyl-1,7-dideoxy-1,7-difluoro-D-glycero-α-D-lyxo-hept-2-ulopyranose

Guidance literature:: With water; Selectfluor; In N,N-dimethyl-formamide; at 20 ℃; for 12h; diastereoselective reaction;
DOI:10.1002/ejoc.201101238

Reference yield: 78.0%

: 1357098-67-9
3,4,5-tri-O-benzyl-1,7-dideoxy-1,7-difluoro-D-glycero-α-D-lyxo-hept-2-ulopyranose

Guidance literature:

Reference yield:

: phenyl 6-deoxy-6-fluoro-1-thio-α-D-mannopyranoside

: 1357098-67-9
3,4,5-tri-O-benzyl-1,7-dideoxy-1,7-difluoro-D-glycero-α-D-lyxo-hept-2-ulopyranose

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 0 - 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: N-Bromosuccinimide; water / acetone / 0.5 h / 20 °C

3.1: acetic anhydride; dimethyl sulfoxide / 12 h / 30 °C

4.1: toluene / 24 h / 60 °C / Inert atmosphere; Darkness

5.1: water; Selectfluor / N,N-dimethyl-formamide / 12 h / 20 °C

With N-Bromosuccinimide; water; acetic anhydride; sodium hydride; dimethyl sulfoxide; Selectfluor; In N,N-dimethyl-formamide; acetone; toluene; mineral oil;
DOI:10.1002/ejoc.201101238