Technology Process of 3-iodo-4-phenoxybenzenesulfonamide
There total 4 articles about 3-iodo-4-phenoxybenzenesulfonamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-amino-4-phenoxybenzenesulfonamide;
With
hydrogenchloride;
In
1,4-dioxane;
at 0 ℃;
for 0.166667h;
Inert atmosphere;
With
sodium nitrite;
In
1,4-dioxane; water;
at 0 ℃;
for 1h;
Inert atmosphere;
With
potassium iodide;
In
1,4-dioxane; water;
at 20 ℃;
for 1h;
Inert atmosphere;
DOI:10.1021/acs.jmedchem.7b00746
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / Inert atmosphere
1.2: 2 h / 20 °C / Inert atmosphere
2.1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 16 h
3.1: hydrogenchloride / 1,4-dioxane / 0.17 h / 0 °C / Inert atmosphere
3.2: 1 h / 0 °C / Inert atmosphere
3.3: 1 h / 20 °C / Inert atmosphere
With
hydrogenchloride; palladium 10% on activated carbon; hydrogen; sodium hydride;
In
1,4-dioxane; ethyl acetate; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/acs.jmedchem.7b00746
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / Inert atmosphere
1.2: 2 h / 20 °C / Inert atmosphere
2.1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 16 h
3.1: hydrogenchloride / 1,4-dioxane / 0.17 h / 0 °C / Inert atmosphere
3.2: 1 h / 0 °C / Inert atmosphere
3.3: 1 h / 20 °C / Inert atmosphere
With
hydrogenchloride; palladium 10% on activated carbon; hydrogen; sodium hydride;
In
1,4-dioxane; ethyl acetate; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/acs.jmedchem.7b00746
