(5R,6S)-3-((S)-1-{1-[(E)-4-Nitro-benzyloxycarbonylimino]-ethyl}-pyrrolidin-3-ylsulfanyl)-7-oxo-6-((R)-1-trimethylsilanyloxy-ethyl)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Base Information

Chemical Name:(5R,6S)-3-((S)-1-{1-[(E)-4-Nitro-benzyloxycarbonylimino]-ethyl}-pyrrolidin-3-ylsulfanyl)-7-oxo-6-((R)-1-trimethylsilanyloxy-ethyl)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester
CAS No.:98167-74-9
Molecular Formula:C₃₃H₃₉N₅O₁₀SSi
Molecular Weight:725.852
Hs Code.:

(5R,6S)-3-((S)-1-{1-[(E)-4-Nitro-benzyloxycarbonylimino]-ethyl}-pyrrolidin-3-ylsulfanyl)-7-oxo-6-((R)-1-trimethylsilanyloxy-ethyl)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Synonyms:(5R,6S)-3-((S)-1-{1-[(E)-4-Nitro-benzyloxycarbonylimino]-ethyl}-pyrrolidin-3-ylsulfanyl)-7-oxo-6-((R)-1-trimethylsilanyloxy-ethyl)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Suppliers and Price of (5R,6S)-3-((S)-1-{1-[(E)-4-Nitro-benzyloxycarbonylimino]-ethyl}-pyrrolidin-3-ylsulfanyl)-7-oxo-6-((R)-1-trimethylsilanyloxy-ethyl)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (5R,6S)-3-((S)-1-{1-[(E)-4-Nitro-benzyloxycarbonylimino]-ethyl}-pyrrolidin-3-ylsulfanyl)-7-oxo-6-((R)-1-trimethylsilanyloxy-ethyl)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (5R,6S)-3-((S)-1-{1-[(E)-4-Nitro-benzyloxycarbonylimino]-ethyl}-pyrrolidin-3-ylsulfanyl)-7-oxo-6-((R)-1-trimethylsilanyloxy-ethyl)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

There total 10 articles about (5R,6S)-3-((S)-1-{1-[(E)-4-Nitro-benzyloxycarbonylimino]-ethyl}-pyrrolidin-3-ylsulfanyl)-7-oxo-6-((R)-1-trimethylsilanyloxy-ethyl)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 92133-50-1
C₃₉H₅₄N₅O₁₄PSSi

: 98167-74-9
(5R,6S)-3-((S)-1-{1-[(E)-4-Nitro-benzyloxycarbonylimino]-ethyl}-pyrrolidin-3-ylsulfanyl)-7-oxo-6-((R)-1-trimethylsilanyloxy-ethyl)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Guidance literature:: hydroquinone; In toluene; at 105 ℃; for 50h;
DOI:10.1016/S0040-4039(01)81292-2

Reference yield:

: 76899-07-5,78963-47-0,78963-48-1,78963-60-7,80951-41-3,81275-02-7,85647-75-2,85954-95-6,92217-74-8,104527-11-9,76855-69-1
(3R,4R)-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-4-acetoxyazetidin-2-one

: 98167-74-9
(5R,6S)-3-((S)-1-{1-[(E)-4-Nitro-benzyloxycarbonylimino]-ethyl}-pyrrolidin-3-ylsulfanyl)-7-oxo-6-((R)-1-trimethylsilanyloxy-ethyl)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 100 percent / Et₃N / tetrahydrofuran / 2 h / Ambient temperature

2: trimethylsilyl trifluoromethanesulfonate / CH₂Cl₂ / Ambient temperature; overnight

3: 91 percent / pyridinium p-toluenesulfonate / tetrahydrofuran; H₂O / 0.5 h / Ambient temperature

4: 100 percent / H₂ / 10percent Pd-C / methanol

5: N,N'-dicyclohexylcarbodiimide / 4-(N,N-dimethylamino)pyridine / benzene

6: Et₃N / CH₂Cl₂ / 0 °C

7: boron trifluoride etherate / acetonitrile

8: 90 percent / DMAP / tetrahydrofuran

9: toluene / 80 - 90 °C / 1-3 hrs

10: 63 percent / hydroquinone / toluene / 50 h / 105 °C

With boron trifluoride diethyl etherate; hydrogen; triethylamine; dicyclohexyl-carbodiimide; dmap; palladium on activated charcoal; trimethylsilyl trifluoromethanesulfonate; pyridinium p-toluenesulfonate; hydroquinone; In tetrahydrofuran; methanol; dichloromethane; water; toluene; acetonitrile; benzene;
DOI:10.1016/S0040-4039(01)81292-2

Reference yield:

: 87392-18-5
<3S-<3α(S^*),4β>>-benzyl<3-(1-t-butyldimethylsilyloxyethyl)-2-azetidinone-4-yl>acetate

: 98167-74-9
(5R,6S)-3-((S)-1-{1-[(E)-4-Nitro-benzyloxycarbonylimino]-ethyl}-pyrrolidin-3-ylsulfanyl)-7-oxo-6-((R)-1-trimethylsilanyloxy-ethyl)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 100 percent / H₂ / 10percent Pd-C / methanol

2: N,N'-dicyclohexylcarbodiimide / 4-(N,N-dimethylamino)pyridine / benzene

3: Et₃N / CH₂Cl₂ / 0 °C

4: boron trifluoride etherate / acetonitrile

5: 90 percent / DMAP / tetrahydrofuran

6: toluene / 80 - 90 °C / 1-3 hrs

7: 63 percent / hydroquinone / toluene / 50 h / 105 °C

With boron trifluoride diethyl etherate; hydrogen; triethylamine; dicyclohexyl-carbodiimide; dmap; palladium on activated charcoal; hydroquinone; In tetrahydrofuran; methanol; dichloromethane; toluene; acetonitrile; benzene;
DOI:10.1016/S0040-4039(01)81292-2