3-(-2-chlorophenyl)-1,3-dihydro-1'-phenoxy carbonylspiro[benzo(c)thiophene-1,4'-piperidine]

Base Information

Chemical Name:3-(-2-chlorophenyl)-1,3-dihydro-1'-phenoxy carbonylspiro[benzo(c)thiophene-1,4'-piperidine]
CAS No.:72364-61-5
Molecular Formula:C₂₅H₂₂ClNO₂S
Molecular Weight:435.974
Hs Code.:

Synonyms:3-(-2-chlorophenyl)-1,3-dihydro-1'-phenoxy carbonylspiro[benzo(c)thiophene-1,4'-piperidine]

Suppliers and Price of 3-(-2-chlorophenyl)-1,3-dihydro-1'-phenoxy carbonylspiro[benzo(c)thiophene-1,4'-piperidine]

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-(-2-chlorophenyl)-1,3-dihydro-1'-phenoxy carbonylspiro[benzo(c)thiophene-1,4'-piperidine]

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-(-2-chlorophenyl)-1,3-dihydro-1'-phenoxy carbonylspiro[benzo(c)thiophene-1,4'-piperidine]

There total 6 articles about 3-(-2-chlorophenyl)-1,3-dihydro-1'-phenoxy carbonylspiro[benzo(c)thiophene-1,4'-piperidine] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1885-14-9
phenyl chloroformate

: 72364-44-4
base 3-(2-chlorophenyl)-1,3-dihydro-1'-methylspiro[benzo(c)thiophene-1,4'-piperidine]

: 72364-61-5
3-(-2-chlorophenyl)-1,3-dihydro-1'-phenoxy carbonylspiro[benzo(c)thiophene-1,4'-piperidine]

Guidance literature:: With sodium hydrogencarbonate; In dichloromethane; for 4h; Ambient temperature;
DOI:10.1021/jm00133a016

Reference yield:

: 1445-73-4
1-Methyl-4-piperidone

: 72364-61-5
3-(-2-chlorophenyl)-1,3-dihydro-1'-phenoxy carbonylspiro[benzo(c)thiophene-1,4'-piperidine]

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) n-BuLi / 1.) THF, -70 deg C, 1 h, 2.) THF, from -60 deg C to RT

2: BF₃, glacial AcOH / 15 h / 60 °C

3: dimsyl sodium / dimethylsulfoxide / 1 h / Ambient temperature

4: 73 percent / NaHCO₃ / CH₂Cl₂ / 4 h / Ambient temperature

With n-butyllithium; boron trifluoride; sodium hydrogencarbonate; sodium methylsulfinylmethanide; acetic acid; In dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm00133a016

Reference yield:

: 1072-85-1
o-fluorobromobenzene

: 72364-61-5
3-(-2-chlorophenyl)-1,3-dihydro-1'-phenoxy carbonylspiro[benzo(c)thiophene-1,4'-piperidine]

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) n-BuLi / 1.) THF, -70 deg C, 1 h, 2.) THF, from -60 deg C to RT

2: BF₃, glacial AcOH / 15 h / 60 °C

3: dimsyl sodium / dimethylsulfoxide / 1 h / Ambient temperature

4: 73 percent / NaHCO₃ / CH₂Cl₂ / 4 h / Ambient temperature

With n-butyllithium; boron trifluoride; sodium hydrogencarbonate; sodium methylsulfinylmethanide; acetic acid; In dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm00133a016