methyl 3-(4-chloro-3-nitrophenyl)-3-(2,2-difluorocyclopropyl)propanoate

Base Information

Chemical Name:methyl 3-(4-chloro-3-nitrophenyl)-3-(2,2-difluorocyclopropyl)propanoate
CAS No.:1402937-40-9
Molecular Formula:C₁₃H₁₂ClF₂NO₄
Molecular Weight:319.692
Hs Code.:

Synonyms:methyl 3-(4-chloro-3-nitrophenyl)-3-(2,2-difluorocyclopropyl)propanoate

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Chemical Property of methyl 3-(4-chloro-3-nitrophenyl)-3-(2,2-difluorocyclopropyl)propanoate

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Technology Process of methyl 3-(4-chloro-3-nitrophenyl)-3-(2,2-difluorocyclopropyl)propanoate

There total 4 articles about methyl 3-(4-chloro-3-nitrophenyl)-3-(2,2-difluorocyclopropyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1402937-36-3
methyl (2Z)-3-(4-chlorophenyl)-3-(2,2-difluorocyclopropyl)acrylate

: 1402937-40-9
methyl 3-(4-chloro-3-nitrophenyl)-3-(2,2-difluorocyclopropyl)propanoate

: 1402937-41-0
methyl 3-(4-chloro-3-nitrophenyl)-5,5-difluorohexanoate

Guidance literature:: methyl (2Z)-3-(4-chlorophenyl)-3-(2,2-difluorocyclopropyl)acrylate; With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 20 ℃; under 760.051 Torr;

With nitronium tetrafluoborate; In dichloromethane; at 0 - 20 ℃; for 3h; Overall yield = 637 mg;

Reference yield:

: 3946-29-0
3,4'-Dichloropropiophenone

: 1402937-40-9
methyl 3-(4-chloro-3-nitrophenyl)-3-(2,2-difluorocyclopropyl)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / acetonitrile / 4 h / 20 °C / Cooling with ice

2.1: 2,6-di-tert-butyl-4-methyl-phenol; sodium fluoride / 0.08 h / 110 °C / Inert atmosphere

2.2: 110 - 125 °C

3.1: sodium hydride / mineral oil; tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

3.2: 2 h / 20 °C / Inert atmosphere

4.1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 20 °C / 760.05 Torr

4.2: 3 h / 0 - 20 °C

With 2,6-di-tert-butyl-4-methyl-phenol; palladium 10% on activated carbon; hydrogen; sodium hydride; sodium fluoride; triethylamine; In tetrahydrofuran; ethyl acetate; acetonitrile; mineral oil;

Reference yield:

: 7448-87-5
p-chlorophenyl vinyl ketone

: 1402937-40-9
methyl 3-(4-chloro-3-nitrophenyl)-3-(2,2-difluorocyclopropyl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2,6-di-tert-butyl-4-methyl-phenol; sodium fluoride / 0.08 h / 110 °C / Inert atmosphere

1.2: 110 - 125 °C

2.1: sodium hydride / mineral oil; tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

3.1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 20 °C / 760.05 Torr

3.2: 3 h / 0 - 20 °C

With 2,6-di-tert-butyl-4-methyl-phenol; palladium 10% on activated carbon; hydrogen; sodium hydride; sodium fluoride; In tetrahydrofuran; ethyl acetate; mineral oil;