2-iodo-6-methoxycarbonyl-3-(methoxymethoxy)methyl-5-methylphenyl 7-chloro-4-hydroxy-5,8-dimethoxy-2-naphthoate

Base Information

Chemical Name:2-iodo-6-methoxycarbonyl-3-(methoxymethoxy)methyl-5-methylphenyl 7-chloro-4-hydroxy-5,8-dimethoxy-2-naphthoate
CAS No.:236751-74-9
Molecular Formula:C₂₅H₂₄ClIO₉
Molecular Weight:630.818
Hs Code.:

Synonyms:2-iodo-6-methoxycarbonyl-3-(methoxymethoxy)methyl-5-methylphenyl 7-chloro-4-hydroxy-5,8-dimethoxy-2-naphthoate

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Chemical Property of 2-iodo-6-methoxycarbonyl-3-(methoxymethoxy)methyl-5-methylphenyl 7-chloro-4-hydroxy-5,8-dimethoxy-2-naphthoate

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Technology Process of 2-iodo-6-methoxycarbonyl-3-(methoxymethoxy)methyl-5-methylphenyl 7-chloro-4-hydroxy-5,8-dimethoxy-2-naphthoate

There total 16 articles about 2-iodo-6-methoxycarbonyl-3-(methoxymethoxy)methyl-5-methylphenyl 7-chloro-4-hydroxy-5,8-dimethoxy-2-naphthoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 236751-48-7
methyl 2-hydroxy-3-iodo-4-(methoxymethoxy)methyl-6-methylbenzoate

: 236751-71-6
7-chloro-4-hydroxy-5,8-dimethoxy-2-naphthoic acid

: 236751-74-9
2-iodo-6-methoxycarbonyl-3-(methoxymethoxy)methyl-5-methylphenyl 7-chloro-4-hydroxy-5,8-dimethoxy-2-naphthoate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 3h;
DOI:10.1002/(SICI)1521-3773(19990503)38:9<1229::AID-ANIE1229>3.0.CO;2-B

Reference yield:

: 22375-05-9
methyl 4-benzyloxy-2-hydroxy-6-methylbenzoate

: 236751-74-9
2-iodo-6-methoxycarbonyl-3-(methoxymethoxy)methyl-5-methylphenyl 7-chloro-4-hydroxy-5,8-dimethoxy-2-naphthoate

Guidance literature:: Multi-step reaction with 9 steps

1: (i-Pr)2NEt / CH₂Cl₂ / 4 h / 40 °C

2: H₂ / Pd(OH)2 / ethyl acetate / 24 h

3: (i-Pr)2NEt / CH₂Cl₂ / 0.5 h / -78 °C

4: 100 percent / Et₃N; 1,1'-bis(diphenylphospanyl)ferrocene / Pd(OAc)2 / dimethylformamide / 3 h / 60 - 80 °C

5: 85 percent / NaBH₄ / dioxane; methanol / 2.5 h / 0 - 20 °C

6: 88 percent / (i-Pr)2NEt / CH₂Cl₂ / 3 h

7: 99 percent / CF₃CO₂H / CH₂Cl₂ / 3 h / 0 °C

8: 99 percent / I₂ / Hg(OAc)2 / CH₂Cl₂ / 1 h / 0 °C

9: 78 percent / EDCI; DMAP / CH₂Cl₂ / 3 h

With dmap; 1,1'-bis-(diphenylphosphino)ferrocene; sodium tetrahydroborate; hydrogen; iodine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium diacetate; palladium dihydroxide; mercury(II) diacetate; In 1,4-dioxane; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 1: Etherification / 2: Hydrogenolysis / 3: Etherification / 4: Substitution / 5: Reduction / 6: Etherification / 7: Hydrogenolysis / 8: Iodination / 9: Esterification;
DOI:10.1002/(SICI)1521-3773(19990503)38:9<1229::AID-ANIE1229>3.0.CO;2-B

Reference yield:

: 603044-66-2
4-hydroxy-2-methoxymethoxy-6-methyl-benzoic acid methyl ester

: 236751-74-9
2-iodo-6-methoxycarbonyl-3-(methoxymethoxy)methyl-5-methylphenyl 7-chloro-4-hydroxy-5,8-dimethoxy-2-naphthoate

Guidance literature:: Multi-step reaction with 7 steps

1: (i-Pr)2NEt / CH₂Cl₂ / 0.5 h / -78 °C

2: 100 percent / Et₃N; 1,1'-bis(diphenylphospanyl)ferrocene / Pd(OAc)2 / dimethylformamide / 3 h / 60 - 80 °C

3: 85 percent / NaBH₄ / dioxane; methanol / 2.5 h / 0 - 20 °C

4: 88 percent / (i-Pr)2NEt / CH₂Cl₂ / 3 h

5: 99 percent / CF₃CO₂H / CH₂Cl₂ / 3 h / 0 °C

6: 99 percent / I₂ / Hg(OAc)2 / CH₂Cl₂ / 1 h / 0 °C

7: 78 percent / EDCI; DMAP / CH₂Cl₂ / 3 h

With dmap; 1,1'-bis-(diphenylphosphino)ferrocene; sodium tetrahydroborate; iodine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium diacetate; mercury(II) diacetate; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; 1: Etherification / 2: Substitution / 3: Reduction / 4: Etherification / 5: Hydrogenolysis / 6: Iodination / 7: Esterification;
DOI:10.1002/(SICI)1521-3773(19990503)38:9<1229::AID-ANIE1229>3.0.CO;2-B