1,2,3,4,5-pentafluorophenyl propargyl ether

Base Information

• Chemical Name: 1,2,3,4,5-pentafluorophenyl propargyl ether
• CAS No.: 52189-72-7
• Molecular Formula: C₉H₃F₅O
• Molecular Weight: 222.114
• Mol file: 52189-72-7.mol

Synonyms:1,2,3,4,5-pentafluorophenyl propargyl ether

Chemical Property of 1,2,3,4,5-pentafluorophenyl propargyl ether

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2,3,4,5-pentafluorophenyl propargyl ether

There total 2 articles about 1,2,3,4,5-pentafluorophenyl propargyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2,3,4,5,6-pentafluorophenol (771-61-9) + propargyl bromide (106-96-7) → 1,2,3,4,5-pentafluorophenyl propargyl ether (52189-72-7)

Guidance literature:

With potassium carbonate; In acetone; toluene; for 6h; Reflux; Inert atmosphere;

DOI:10.1002/anie.201606760

Reference yield:

→ 1,2,3,4,5-pentafluorophenyl propargyl ether (52189-72-7)

Guidance literature:

Propargylalkohol, NaH, Hexafluorbenzol;

Reference yield: 96.0%

1,2,3,4,5-pentafluorophenyl propargyl ether (52189-72-7) + 2-nitroacetophenone (614-21-1) → (5-((perfluorophenoxy)methyl)isoxazol-3-yl)(phenyl)methanone

Guidance literature:

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; oxygen; In water; at 60 ℃; for 4h; Green chemistry;

DOI:10.1021/acs.joc.9b01896

upstream raw materials:

2,3,4,5,6-pentafluorophenol

propargyl bromide

Downstream raw materials:

2-(2,5-dimethylbenzyl)-4,5,6,7-tetrafluorobenzofuran

2-methyl-4,5,6,7-tetrafluorobenzofuran

2,3,4,5,6-pentafluorophenol

2-methyl-6-pentafluorophenoxy-4,5,7-trifluorobenzofuran