(+/-)-methylthiocarbamic acid 1-(4-methoxyphenyl)-1-p-tolylethyl ester

Base Information

Chemical Name:(+/-)-methylthiocarbamic acid 1-(4-methoxyphenyl)-1-p-tolylethyl ester
CAS No.:1292296-74-2
Molecular Formula:C₁₈H₂₁NO₂S
Molecular Weight:315.436
Hs Code.:

Synonyms:(+/-)-methylthiocarbamic acid 1-(4-methoxyphenyl)-1-p-tolylethyl ester

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Chemical Property of (+/-)-methylthiocarbamic acid 1-(4-methoxyphenyl)-1-p-tolylethyl ester

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Technology Process of (+/-)-methylthiocarbamic acid 1-(4-methoxyphenyl)-1-p-tolylethyl ester

There total 4 articles about (+/-)-methylthiocarbamic acid 1-(4-methoxyphenyl)-1-p-tolylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1292296-63-9
methyl-p-tolylthiocarbamic acid 1-(4-methoxyphenyl)ethyl ester

: 1292296-74-2
(+/-)-methylthiocarbamic acid 1-(4-methoxyphenyl)-1-p-tolylethyl ester

Guidance literature:: methyl-p-tolylthiocarbamic acid 1-(4-methoxyphenyl)ethyl ester; With 2,2,6,6-tetramethylpiperidinyl-lithium; In tetrahydrofuran; hexanes; at -78 ℃; for 15h;

With propionic acid; In tetrahydrofuran; hexanes; at -78 - 20 ℃;
DOI:10.1039/c0cc04912c

Reference yield:

: C₁₁H₁₄O₂S

: 1292296-74-2
(+/-)-methylthiocarbamic acid 1-(4-methoxyphenyl)-1-p-tolylethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / Reflux

1.3: 72 h

2.1: 2,2,6,6-tetramethylpiperidinyl-lithium / tetrahydrofuran; hexanes / 15 h / -78 °C

2.2: -78 - 20 °C

With lithium aluminium tetrahydride; 2,2,6,6-tetramethylpiperidinyl-lithium; In tetrahydrofuran; hexanes; diethyl ether;
DOI:10.1039/c0cc04912c

Reference yield:

: 1517-70-0,1572-97-0,3319-15-1,43230-31-5
(S)-1-(4-Methoxyphenyl)ethanol

: 1292296-74-2
(+/-)-methylthiocarbamic acid 1-(4-methoxyphenyl)-1-p-tolylethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride; triethylamine; N,N-dimethyl-formamide / dichloromethane / 18 h / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / Reflux

2.3: 72 h

3.1: 2,2,6,6-tetramethylpiperidinyl-lithium / tetrahydrofuran; hexanes / 15 h / -78 °C

3.2: -78 - 20 °C

With lithium aluminium tetrahydride; oxalyl dichloride; 2,2,6,6-tetramethylpiperidinyl-lithium; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; hexanes; diethyl ether; dichloromethane;
DOI:10.1039/c0cc04912c