4-[7-(4-cyano-2-trifluoromethyl-phenyl)-8-oxo-6-thio-5,7-diazaspiro[3,4]-5-octyl]-2-fluoro-N-methyl benzamide

Base Information

Chemical Name:4-[7-(4-cyano-2-trifluoromethyl-phenyl)-8-oxo-6-thio-5,7-diazaspiro[3,4]-5-octyl]-2-fluoro-N-methyl benzamide
CAS No.:1245736-63-3
Molecular Formula:C₂₂H₁₆F₄N₄O₂S
Molecular Weight:476.454
Hs Code.:

Synonyms:4-[7-(4-cyano-2-trifluoromethyl-phenyl)-8-oxo-6-thio-5,7-diazaspiro[3,4]-5-octyl]-2-fluoro-N-methyl benzamide

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Chemical Property of 4-[7-(4-cyano-2-trifluoromethyl-phenyl)-8-oxo-6-thio-5,7-diazaspiro[3,4]-5-octyl]-2-fluoro-N-methyl benzamide

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Technology Process of 4-[7-(4-cyano-2-trifluoromethyl-phenyl)-8-oxo-6-thio-5,7-diazaspiro[3,4]-5-octyl]-2-fluoro-N-methyl benzamide

There total 5 articles about 4-[7-(4-cyano-2-trifluoromethyl-phenyl)-8-oxo-6-thio-5,7-diazaspiro[3,4]-5-octyl]-2-fluoro-N-methyl benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 285125-02-2
4-isothiocyanato-3-(trifluoromethyl)benzonitrile

: 915087-26-2
4-(1-cyano-cyclobutanylamino)-2-fluoro-N-methyl-benzamide

: 1245736-63-3
4-[7-(4-cyano-2-trifluoromethyl-phenyl)-8-oxo-6-thio-5,7-diazaspiro[3,4]-5-octyl]-2-fluoro-N-methyl benzamide

Guidance literature:: 4-isothiocyanato-3-(trifluoromethyl)benzonitrile; 4-(1-cyano-cyclobutanylamino)-2-fluoro-N-methyl-benzamide; In N,N-dimethyl-formamide; at 110 ℃; for 12h; Microwave irradiation;

hydrogenchloride; In ethanol; N,N-dimethyl-formamide; for 1h; Reflux;

Reference yield: 11.0%

: 915087-26-2
4-(1-cyano-cyclobutanylamino)-2-fluoro-N-methyl-benzamide

: 4-isothiocyanato-2-(trifluoromethyl)-benzyl cyanide

: 1245736-63-3
4-[7-(4-cyano-2-trifluoromethyl-phenyl)-8-oxo-6-thio-5,7-diazaspiro[3,4]-5-octyl]-2-fluoro-N-methyl benzamide

Guidance literature:: With hydrogenchloride; In ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 915087-25-1
2-fluoro-N-methyl-4-amino-benzamide

: 1245736-63-3
4-[7-(4-cyano-2-trifluoromethyl-phenyl)-8-oxo-6-thio-5,7-diazaspiro[3,4]-5-octyl]-2-fluoro-N-methyl benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid / 24 h / 80 °C

2.1: N,N-dimethyl-formamide / 12 h / 110 °C / Microwave irradiation

2.2: 1 h / Reflux

With acetic acid; In N,N-dimethyl-formamide;