5'-O-(dimethoxytrityl)-N²-isobutyryl-2'-O-(o-nitrobenzyl)-3'-thioguanosine-3'-S-(cyanoethyl-N,N-diisopropylphosphoramidite)

Base Information

• Chemical Name: 5'-O-(dimethoxytrityl)-N²-isobutyryl-2'-O-(o-nitrobenzyl)-3'-thioguanosine-3'-S-(cyanoethyl-N,N-diisopropylphosphoramidite)
• CAS No.: 1586816-14-9
• Molecular Formula: C₅₁H₅₉N₈O₁₀PS
• Molecular Weight: 1007.12

Synonyms:5'-O-(dimethoxytrityl)-N²-isobutyryl-2'-O-(o-nitrobenzyl)-3'-thioguanosine-3'-S-(cyanoethyl-N,N-diisopropylphosphoramidite)

Chemical Property of 5'-O-(dimethoxytrityl)-N²-isobutyryl-2'-O-(o-nitrobenzyl)-3'-thioguanosine-3'-S-(cyanoethyl-N,N-diisopropylphosphoramidite)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-O-(dimethoxytrityl)-N²-isobutyryl-2'-O-(o-nitrobenzyl)-3'-thioguanosine-3'-S-(cyanoethyl-N,N-diisopropylphosphoramidite)

There total 8 articles about 5'-O-(dimethoxytrityl)-N²-isobutyryl-2'-O-(o-nitrobenzyl)-3'-thioguanosine-3'-S-(cyanoethyl-N,N-diisopropylphosphoramidite) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

5'-O-(dimethoxytrityl)-N2-isobutyryl-2'-O-(o-nitrobenzyl)-3'-thioguanosine (1586816-13-8) + 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine (124482-92-4,89992-70-1) → 5'-O-(dimethoxytrityl)-N2-isobutyryl-2'-O-(o-nitrobenzyl)-3'-thioguanosine-3'-S-(cyanoethyl-N,N-diisopropylphosphoramidite) (1586816-14-9)

Guidance literature:

With 1-methyl-1H-imidazole; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/jo4028374

Reference yield:

3'-S-acetyl-N2-isobutyryl-2'-O-(o-nitrobenzyl)-3'-thioguanosine → 5'-O-(dimethoxytrityl)-N2-isobutyryl-2'-O-(o-nitrobenzyl)-3'-thioguanosine-3'-S-(cyanoethyl-N,N-diisopropylphosphoramidite) (1586816-14-9)

Guidance literature:

Multi-step reaction with 4 steps

1: acetic acid; tetra-n-butylammoniumfluoride trihydrate / 14 h / 20 °C

2: pyridine / 24 h / 20 °C / Inert atmosphere

3: guanidine hydrochloride; sodium methylate / dichloromethane; methanol / 3 h / 0 - 20 °C

4: N-ethyl-N,N-diisopropylamine; 1-methyl-1H-imidazole / dichloromethane / 1 h / 20 °C / Inert atmosphere

With 1-methyl-1H-imidazole; guanidine hydrochloride; sodium methylate; acetic acid; tetra-n-butylammoniumfluoride trihydrate; N-ethyl-N,N-diisopropylamine; In pyridine; methanol; dichloromethane;

DOI:10.1021/jo4028374

Reference yield:

N2-isobutyryl-2'-O-(o-nitrobenzyl)guanosine (64350-25-0) → 5'-O-(dimethoxytrityl)-N2-isobutyryl-2'-O-(o-nitrobenzyl)-3'-thioguanosine-3'-S-(cyanoethyl-N,N-diisopropylphosphoramidite) (1586816-14-9)

Guidance literature:

Multi-step reaction with 8 steps

1: sodium hydride / pyridine / 24 h / 20 °C / Inert atmosphere

2: dmap / dichloromethane / 3 h / 0 °C

3: sodium bromide / acetone / 23 h / Reflux; Inert atmosphere

4: N,N-dimethyl-formamide / 7 h / 60 °C / Inert atmosphere

5: acetic acid; tetra-n-butylammoniumfluoride trihydrate / 14 h / 20 °C

6: pyridine / 24 h / 20 °C / Inert atmosphere

7: guanidine hydrochloride; sodium methylate / dichloromethane; methanol / 3 h / 0 - 20 °C

8: N-ethyl-N,N-diisopropylamine; 1-methyl-1H-imidazole / dichloromethane / 1 h / 20 °C / Inert atmosphere

With 1-methyl-1H-imidazole; dmap; guanidine hydrochloride; sodium methylate; sodium hydride; acetic acid; tetra-n-butylammoniumfluoride trihydrate; N-ethyl-N,N-diisopropylamine; sodium bromide; In pyridine; methanol; dichloromethane; N,N-dimethyl-formamide; acetone;

DOI:10.1021/jo4028374

upstream raw materials:

N²-isobutyryl-2'-deoxyguanosine

2-nitrophenylmethyl bromide

N²-isobutyryl-2'-O-(o-nitrobenzyl)guanosine

5'-O-(dimethoxytrityl)-N²-isobutyryl-2'-O-(o-nitrobenzyl)-3'-thioguanosine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1586816-14-9 5'-O-(dimethoxytrityl)-N²-isobutyryl-2'-O-(o-nitrobenzyl)-3'-thioguanosine-3'-S-(cyanoethyl-N,N-diisopropylphosphoramidite)

Send

Send

Metric Ton KG G Pound L ML

Send

Send