1-(3-Carbamoyl-5-(4-methoxyphenyl)thiophen-2-yl)urea

Base Information

Chemical Name:1-(3-Carbamoyl-5-(4-methoxyphenyl)thiophen-2-yl)urea
CAS No.:354812-11-6
Molecular Formula:C₁₃H₁₃N₃O₃S
Molecular Weight:291.331
Hs Code.:
DSSTox Substance ID:DTXSID501162022
ChEMBL ID:CHEMBL452272

Synonyms:CHEMBL452272;SCHEMBL4089013;DTXSID501162022;BDBM50243419;1-(3-carbamoyl-5-(4-methoxyphenyl)thiophen-2-yl)urea;2-[(aminocarbonyl)amino]-5-(4-methoxyphenyl)-3-thiophenecarboxamide;354812-11-6

Suppliers and Price of 1-(3-Carbamoyl-5-(4-methoxyphenyl)thiophen-2-yl)urea

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(3-Carbamoyl-5-(4-methoxyphenyl)thiophen-2-yl)urea

Chemical Property:

XLogP3:1.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:291.06776246
Heavy Atom Count:20
Complexity:372

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C2=CC(=C(S2)NC(=O)N)C(=O)N

Technology Process of 1-(3-Carbamoyl-5-(4-methoxyphenyl)thiophen-2-yl)urea

There total 3 articles about 1-(3-Carbamoyl-5-(4-methoxyphenyl)thiophen-2-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 354812-10-5
2-[(aminocarbonyl)amino]-5-bromo-3-thiophenecarboxamide

: 171364-79-7
2-(4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 354812-11-6
5-(4-methoxyphenyl)-2-ureidothiophene-3-carboxamide

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In 1,4-dioxane; water; at 75 ℃; for 18h; Inert atmosphere;
DOI:10.3987/COM-19-S(F)43

Reference yield:

: 339365-14-9
1-(3-carbamoylthiophen-2-yl)urea

: 354812-11-6
5-(4-methoxyphenyl)-2-ureidothiophene-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide / tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere; Darkness

2: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 18 h / 75 °C / Inert atmosphere

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; water; 2: |Suzuki-Miyaura Coupling;
DOI:10.3987/COM-19-S(F)43

Reference yield:

: 14080-51-4
2-aminothiophene-3-carboxamide

: 354812-11-6
5-(4-methoxyphenyl)-2-ureidothiophene-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetonitrile / 3.5 h / 0 - 20 °C / Inert atmosphere

1.2: 15 h / 0 - 20 °C / Inert atmosphere

2.1: N-Bromosuccinimide / tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere; Darkness

3.1: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 18 h / 75 °C / Inert atmosphere

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; water; acetonitrile; 3.1: |Suzuki-Miyaura Coupling;
DOI:10.3987/COM-19-S(F)43