Technology Process of methyl 5-phenoxyindane-2-carboxylate
There total 5 articles about methyl 5-phenoxyindane-2-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methyl 5-hydroxyindane-2-carboxylate; phenylboronic acid;
With
copper diacetate;
In
dichloromethane;
at 20 ℃;
for 0.25h;
Molecular sieve;
With
triethylamine;
In
dichloromethane;
at 20 ℃;
for 17h;
Inert atmosphere;
DOI:10.1021/jm101597x
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydride / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux
2.1: palladium 10% on activated carbon; perchloric acid; hydrogen; acetic acid / 16 h
3.1: water; hydrogen bromide; acetic acid / 2 h / Inert atmosphere; Reflux
4.1: sulfuric acid / 1 h / Inert atmosphere; Reflux
5.1: copper diacetate / dichloromethane / 0.25 h / 20 °C / Molecular sieve
5.2: 17 h / 20 °C / Inert atmosphere
With
perchloric acid; sulfuric acid; palladium 10% on activated carbon; water; hydrogen bromide; hydrogen; copper diacetate; sodium hydride; acetic acid;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/jm101597x
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: palladium 10% on activated carbon; perchloric acid; hydrogen; acetic acid / 16 h
2.1: water; hydrogen bromide; acetic acid / 2 h / Inert atmosphere; Reflux
3.1: sulfuric acid / 1 h / Inert atmosphere; Reflux
4.1: copper diacetate / dichloromethane / 0.25 h / 20 °C / Molecular sieve
4.2: 17 h / 20 °C / Inert atmosphere
With
perchloric acid; sulfuric acid; palladium 10% on activated carbon; water; hydrogen bromide; hydrogen; copper diacetate; acetic acid;
In
dichloromethane;
DOI:10.1021/jm101597x
