4-[(2-Chloromethyl-7-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-methyl-amino]-2-fluoro-N-(3-nitro-benzyl)-benzamide

Base Information

Chemical Name:4-[(2-Chloromethyl-7-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-methyl-amino]-2-fluoro-N-(3-nitro-benzyl)-benzamide
CAS No.:173952-28-8
Molecular Formula:C₂₆H₂₃ClFN₅O₄
Molecular Weight:523.951
Hs Code.:

Synonyms:4-[(2-Chloromethyl-7-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-methyl-amino]-2-fluoro-N-(3-nitro-benzyl)-benzamide

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Chemical Property of 4-[(2-Chloromethyl-7-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-methyl-amino]-2-fluoro-N-(3-nitro-benzyl)-benzamide

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Technology Process of 4-[(2-Chloromethyl-7-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-methyl-amino]-2-fluoro-N-(3-nitro-benzyl)-benzamide

There total 13 articles about 4-[(2-Chloromethyl-7-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-methyl-amino]-2-fluoro-N-(3-nitro-benzyl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 173952-26-6
2-Fluoro-4-[(2-hydroxymethyl-7-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-methyl-amino]-N-(3-nitro-benzyl)-benzamide

: 173952-28-8
4-[(2-Chloromethyl-7-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-methyl-amino]-2-fluoro-N-(3-nitro-benzyl)-benzamide

Guidance literature:: With thionyl chloride; In dichloromethane; for 1h;
DOI:10.1021/jm950645n

Reference yield:

: 7409-18-9
3-nitrobenzylamine

: 173952-28-8
4-[(2-Chloromethyl-7-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-methyl-amino]-2-fluoro-N-(3-nitro-benzyl)-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: diphenyl phosphorazidate, triethylamine / dimethylformamide / 16 h

2: 44 percent / CaCO₃ / dimethylformamide / 18 h / 80 °C

3: 70 percent / 1 N aq. NaOH / methanol / 4 h

4: SOCl₂ / CH₂Cl₂ / 1 h

With sodium hydroxide; thionyl chloride; diphenyl phosphoryl azide; triethylamine; calcium carbonate; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm950645n

Reference yield:

: 140373-77-9
tert-butyl 2-fluoro-4-aminobenzoate

: 173952-28-8
4-[(2-Chloromethyl-7-methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-methyl-amino]-2-fluoro-N-(3-nitro-benzyl)-benzamide

Guidance literature:: Multi-step reaction with 8 steps

1: 89 percent / Na₂CO₃ / CH₂Cl₂ / 2 h

2: Na₂CO₃ / dimethylformamide

3: 7percent aq. K₂CO₃ / methanol / 3 h

4: 84 percent / trifluoroacetic acid / CH₂Cl₂ / 3 h

5: diphenyl phosphorazidate, triethylamine / dimethylformamide / 16 h

6: 44 percent / CaCO₃ / dimethylformamide / 18 h / 80 °C

7: 70 percent / 1 N aq. NaOH / methanol / 4 h

8: SOCl₂ / CH₂Cl₂ / 1 h

With sodium hydroxide; thionyl chloride; diphenyl phosphoryl azide; sodium carbonate; potassium carbonate; triethylamine; trifluoroacetic acid; calcium carbonate; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm950645n