dimethyl 3-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-4,5-isothiazoledicarboxylate

Base Information

• Chemical Name: dimethyl 3-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-4,5-isothiazoledicarboxylate
• CAS No.: 136035-16-0
• Molecular Formula: C₃₃H₂₇NO₁₁S
• Molecular Weight: 645.643
• Mol file: 136035-16-0.mol

Synonyms:dimethyl 3-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-4,5-isothiazoledicarboxylate

Chemical Property of dimethyl 3-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-4,5-isothiazoledicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethyl 3-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-4,5-isothiazoledicarboxylate

There total 4 articles about dimethyl 3-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-4,5-isothiazoledicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

dimethyl 3-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-isothiazoline-4,5-dicarboxylate → dimethyl 3-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-4,5-isothiazoledicarboxylate (136035-16-0)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In chlorobenzene; for 4.5h; Heating;

DOI:10.1080/15257779408013275

Reference yield: 8.0%

5-(2',3',5'-tri-O-benzoyl-β-D-ribofuranosyl)-1,3,4-oxathiazol-2-one (89873-12-1) + dimethyl acetylenedicarboxylate (762-42-5) → dimethyl 3-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-4,5-isothiazoledicarboxylate (136035-16-0)

Guidance literature:

at 140 ℃; for 144h;

DOI:10.1080/15257779408013275

Reference yield:

5-(2',3',5'-tri-O-benzoyl-β-D-ribofuranosyl)-1,3,4-oxathiazol-2-one (89873-12-1) → dimethyl 3-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-4,5-isothiazoledicarboxylate (136035-16-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 58 percent / 0.75 h / 200 °C

2: 85 percent / DDQ / chlorobenzene / 4.5 h / Heating

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In chlorobenzene;

DOI:10.1080/15257779408013275

upstream raw materials:

5-(2',3',5'-tri-O-benzoyl-β-D-ribofuranosyl)-1,3,4-oxathiazol-2-one

dimethyl acetylenedicarboxylate

dimethylfumarate