N-(4-bromomethyl-5'-chloro-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3'-yl)-3-chloro-benzamide

Base Information

Chemical Name:N-(4-bromomethyl-5'-chloro-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3'-yl)-3-chloro-benzamide
CAS No.:1314530-71-6
Molecular Formula:C₁₉H₂₀BrCl₂N₃O
Molecular Weight:457.197
Hs Code.:

Synonyms:N-(4-bromomethyl-5'-chloro-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3'-yl)-3-chloro-benzamide

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Chemical Property of N-(4-bromomethyl-5'-chloro-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3'-yl)-3-chloro-benzamide

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Technology Process of N-(4-bromomethyl-5'-chloro-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3'-yl)-3-chloro-benzamide

There total 7 articles about N-(4-bromomethyl-5'-chloro-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3'-yl)-3-chloro-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 1314530-70-5
3-chloro-N-[5'-chloro-4-(1-hydroxy-ethyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3'-yl]-benzamide

: 1314530-71-6
N-(4-bromomethyl-5'-chloro-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3'-yl)-3-chloro-benzamide

Guidance literature:: 3-chloro-N-[5'-chloro-4-(1-hydroxy-ethyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3'-yl]-benzamide; With triphenylphosphine; In dichloromethane; at 0 ℃; Inert atmosphere;

With carbon tetrabromide; In dichloromethane; at 0 ℃; for 0.5h;

Reference yield:

: 183170-69-6
1-tert-Butyloxycarbonyl-4-hydroxyethyl-piperidine

: 1314530-71-6
N-(4-bromomethyl-5'-chloro-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3'-yl)-3-chloro-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; methanol / diethyl ether / 20 °C

2.1: acetonitrile / 14 h / 175 °C / Microwave irradiation

3.1: triphenylphosphine / dichloromethane / 0 °C / Inert atmosphere

3.2: 0.5 h / 0 °C

With hydrogenchloride; methanol; triphenylphosphine; In diethyl ether; dichloromethane; acetonitrile;

Reference yield:

: 206989-61-9
4-acetyl-1-(t-butoxycarbonyl)piperidine

: 1314530-71-6
N-(4-bromomethyl-5'-chloro-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3'-yl)-3-chloro-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium tetrahydroborate / ethanol / 1 h / 20 °C

2.1: hydrogenchloride; methanol / diethyl ether / 20 °C

3.1: acetonitrile / 14 h / 175 °C / Microwave irradiation

4.1: triphenylphosphine / dichloromethane / 0 °C / Inert atmosphere

4.2: 0.5 h / 0 °C

With hydrogenchloride; methanol; sodium tetrahydroborate; triphenylphosphine; In diethyl ether; ethanol; dichloromethane; acetonitrile;