206989-61-9

Basic information

• Product Name: 4-ACETYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• Synonyms: 4-ACETYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-N-Boc-4-Acetylpiperidine;N-Boc-4-acetylpiperidine;tert-Butyl 4-acetylpiperidine-1-carboxylate;1-BOC-ESTER4-ACETYL-PIPERIDINE;1-tert-Butoxycarbonyl-4-acetylpiperidine;1-Piperidinecarboxylic acid, 4-acetyl-, 1,1-dimethylethyl ester;1-BOC-4-ACETYL-PIPERIDINE
• CAS NO: 206989-61-9
• Molecular Formula: C₁₂H₂₁NO₃
• Molecular Weight: 227.3
• Mol File: 206989-61-9.mol
• Article Data: 28

Chemical Properties

• Boiling Point: 312.365 °C at 760 mmHg
• Flash Point: 142.714 °C
• Appearance: /
• Density: 1.053 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.474
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: -2.23±0.40(Predicted)
• CAS DataBase Reference: 4-ACETYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ACETYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(206989-61-9)
• EPA Substance Registry System: 4-ACETYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(206989-61-9)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• RIDADR: UN 2811 6.1 / PGIII
• HazardClass: IRRITANT
• Hazardous Substances Data: 206989-61-9(Hazardous Substances Data)

Usage

Appearance

Light yellow oil

Uses

tert-Butyl 4-Acetylpiperidine-1-carboxylate is a useful research chemical.

InChI:InChI=1/C12H21NO3/c1-9(14)10-5-7-13(8-6-10)11(15)16-12(2,3)4/h10H,5-8H2,1-4H3

Upstream product

• 139290-70-3 tert-butyl 4-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate 
• 203664-61-3 4-(2,2-dibromo-vinyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 287192-97-6 4-ethynyl-piperidine-1-carboxylic acid tert-butyl ester 
• 137076-22-3 tert butyl 4-formylpiperidine-1-carboxylate 
• 142851-03-4 1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate 
• 1126-09-6 4-carbethoxypiperidine 
• 498-94-2 isonipecotic acid 
• 479630-08-5 4-(2-ethoxycarbonylacetyl)piperidine-1-carboxylic acid tert-butyl ester 
• 782493-40-7 tert-butyl 4-[(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)(hydroxy)methyl]piperidine-1-carboxylate 
• 75-16-1 methylmagnesium bromide 
• 91419-52-2 1-tert-butoxycarbonyl-4-cyanopiperidine 
• 676-58-4 methylmagnesium chloride 
• 91419-48-6 4-carbamoyl-piperidine-1-carboxylic acid tert-butyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 301219-11-4 1-(1-(tert-Butoxycarbonyl)piperidin-4-yl)-4-phenyl-butane-1,3-dione 
• 479630-02-9 4-(2-methoxycarbonylacetyl)piperidine-1-carboxylic acid tert-butyl ester 
• 1346529-76-7 tert-butyl 4-(1-(2-bromophenyl)-2-hydroxypropan-2-yl)piperidine-1-carboxylate 
• 89895-06-7 1-(piperidin-4-yl)ethan-1-one hydrochloride 
• 20691-91-2 1-(1-methylpiperidin-4-yl)ethanone 
• 1357172-38-3 C₂₃H₂₉N₃O₅S 
• 1357172-44-1 C₂₄H₃₁N₃O₅S 
• 1344668-98-9 2-(1-acetylpiperidin-4-yl)-4-(2-chlorophenyl)-8-(2,6-difluorophenyl)-1,7-naphthyridine 7-oxide 
• 206989-62-0 tert-butyl 4-(1,8-naphthyridin-2-yl)piperidine-1-carboxylate 
• 206989-63-1 tert-butyl 4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)piperidine-1-carboxylate 
• 1314530-71-6 N-(4-bromomethyl-5'-chloro-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3'-yl)-3-chloro-benzamide 
• 1314530-70-5 3-chloro-N-[5'-chloro-4-(1-hydroxy-ethyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-3'-yl]-benzamide 
• 1314528-14-7 C₂₄H₃₀Cl₂N₄O 
• 6457-48-3 4-(1-hydroxyethyl)piperidine 

Relevant articles and documents

Meso-piperidine calix[4]pyrrole: Synthesis, structure and ion binding studies

We report the synthesis, structure and preliminary solution phase ion binding properties of the calix[4]pyrrole 3a-c. Calix[4]pyrrole 3a and 3b, the first to be prepared via one-pot reaction, were obtained by reacting the ketone 7 with pyrrole in the presence of an acid catalyst. On the basis of 1H NMR spectroscopic analyses and the titrations of UV spectrophotometry, it was concluded that compound 3a possesses significantly enhanced selectivity for fluoride anion in chloroform, and formes 1:1 (ligand: anion) complexes with fluoride and chloride anions.

TRPML MODULATORS

The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.

TREATMENT OF INDOLENT OR AGGRESSIVE B-CELL LYMPHOMAS USING A COMBINATION COMPRISING BTK INHIBITORS

Disclosed herein is a method for the prevention, delay of progression or treatment of indolent or aggressive B-cell lymphomas in an individual in need thereof, comprising administering a Btk inhibitor (in particularly (S)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo-[1,5-a]pyrimidine-3-carboxamide or a pharmaceutically acceptable salt thereof) in combination with an anti-PD-1 antibody. The potent and selective BTK inhibitor in combination with the anti-PD-1 antibody have a manageable toxicity profile in patients with indolent and aggressive lymphomas.