(E)-methyl-3-(2-(2-(tert-butoxycarbonylamino)phenyl)-1-tosyl-4,5-dihydro-1H-pyrrol-3-yl)acrylate

Base Information

Chemical Name:(E)-methyl-3-(2-(2-(tert-butoxycarbonylamino)phenyl)-1-tosyl-4,5-dihydro-1H-pyrrol-3-yl)acrylate
CAS No.:1620090-41-6
Molecular Formula:C₂₆H₃₀N₂O₆S
Molecular Weight:498.6
Hs Code.:

Synonyms:(E)-methyl-3-(2-(2-(tert-butoxycarbonylamino)phenyl)-1-tosyl-4,5-dihydro-1H-pyrrol-3-yl)acrylate

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Chemical Property of (E)-methyl-3-(2-(2-(tert-butoxycarbonylamino)phenyl)-1-tosyl-4,5-dihydro-1H-pyrrol-3-yl)acrylate

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Technology Process of (E)-methyl-3-(2-(2-(tert-butoxycarbonylamino)phenyl)-1-tosyl-4,5-dihydro-1H-pyrrol-3-yl)acrylate

There total 4 articles about (E)-methyl-3-(2-(2-(tert-butoxycarbonylamino)phenyl)-1-tosyl-4,5-dihydro-1H-pyrrol-3-yl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1620090-36-9
tert-butyl-2-(3-iodo-1-tosyl-4,5-dihydro-1H-pyrrol-2-yl)phenylcarbamate

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 1620090-41-6
(E)-methyl-3-(2-(2-(tert-butoxycarbonylamino)phenyl)-1-tosyl-4,5-dihydro-1H-pyrrol-3-yl)acrylate

Guidance literature:: With trans-bis(triphenylphosphine)palladium dichloride; triethylamine; In N,N-dimethyl-formamide; at 80 ℃; Inert atmosphere;
DOI:10.1039/c4cc02466d

Reference yield:

: 1620090-31-4
tert-butyl-2-(4-(4-methylphenylsulfonamido)but-1-ynyl)phenylcarbamate

: 1620090-41-6
(E)-methyl-3-(2-(2-(tert-butoxycarbonylamino)phenyl)-1-tosyl-4,5-dihydro-1H-pyrrol-3-yl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; iodine / acetonitrile / 0 - 20 °C / Inert atmosphere

2: triethylamine; trans-bis(triphenylphosphine)palladium dichloride / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

With trans-bis(triphenylphosphine)palladium dichloride; iodine; potassium carbonate; triethylamine; In N,N-dimethyl-formamide; acetonitrile; 2: |Heck Reaction;
DOI:10.1039/c4cc02466d

Reference yield:

: 161117-84-6
tert-butyl 2-iodophenylcarbamate

: 1620090-41-6
(E)-methyl-3-(2-(2-(tert-butoxycarbonylamino)phenyl)-1-tosyl-4,5-dihydro-1H-pyrrol-3-yl)acrylate

Guidance literature:: Multi-step reaction with 3 steps

1: trans-bis(triphenylphosphine)palladium dichloride; copper(l) iodide / triethylamine / 6 h / 20 °C

2: potassium carbonate; iodine / acetonitrile / 0 - 20 °C / Inert atmosphere

3: triethylamine; trans-bis(triphenylphosphine)palladium dichloride / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

With copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; iodine; potassium carbonate; triethylamine; In triethylamine; N,N-dimethyl-formamide; acetonitrile; 3: |Heck Reaction;
DOI:10.1039/c4cc02466d