8-{3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-oxo-tetrahydro-furan-2-yl}-4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-8H-pyrido[2,3-d]pyrimidin-5-one

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Chemical Name:8-{3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-oxo-tetrahydro-furan-2-yl}-4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-8H-pyrido[2,3-d]pyrimidin-5-one
CAS No.:306960-37-2
Molecular Formula:C₇₅H₆₆N₄O₁₁
Molecular Weight:1199.37
Hs Code.:

8-{3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-oxo-tetrahydro-furan-2-yl}-4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-8<i>H</i>-pyrido[2,3-<i>d</i>]pyrimidin-5-one

Synonyms:8-{3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-oxo-tetrahydro-furan-2-yl}-4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-8H-pyrido[2,3-d]pyrimidin-5-one

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Chemical Property of 8-{3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-oxo-tetrahydro-furan-2-yl}-4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-8H-pyrido[2,3-d]pyrimidin-5-one

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Technology Process of 8-{3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-oxo-tetrahydro-furan-2-yl}-4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-8H-pyrido[2,3-d]pyrimidin-5-one

There total 9 articles about 8-{3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-oxo-tetrahydro-furan-2-yl}-4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-8H-pyrido[2,3-d]pyrimidin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 8-{3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-8H-pyrido[2,3-d]pyrimidin-5-one

: 306960-37-2
8-{3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-oxo-tetrahydro-furan-2-yl}-4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-8H-pyrido[2,3-d]pyrimidin-5-one

Guidance literature:: With dichloro-acetic acid; dicyclohexyl-carbodiimide; In dimethyl sulfoxide; toluene; at 20 ℃; for 20h;
DOI:10.1021/jm000073t

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 306960-37-2
8-{3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-oxo-tetrahydro-furan-2-yl}-4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-8H-pyrido[2,3-d]pyrimidin-5-one

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / 96 h / 60 °C

2: NH₃ / methanol / 20 h / 20 °C

3: pyridine / 2 h / 0 °C

4: DCC; dichloroacetic acid / toluene; dimethylsulfoxide / 20 h / 20 °C

With pyridine; dichloro-acetic acid; ammonia; dicyclohexyl-carbodiimide; In methanol; dimethyl sulfoxide; toluene;
DOI:10.1021/jm000073t

Reference yield:

: 98651-70-8
2-amino-4-methoxypyridine-3-carbonitrile

: 306960-37-2
8-{3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-oxo-tetrahydro-furan-2-yl}-4-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-8H-pyrido[2,3-d]pyrimidin-5-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: 80 percent / acetonitrile / 20 h / Heating

2.1: 89 percent / 2-ethoxy-ethanol / 30 h / Heating

3.1: N,O-bis(trimethylsilyl)acetamide / 1,2-dichloro-ethane / 2 h / 75 °C

3.2: trimethylsilyl triflate / 1,2-dichloro-ethane / 72 h / Heating

4.1: H₂NNH₂; pyridine; AcOH / 20 h / 20 °C

5.1: pyridine / 96 h / 60 °C

6.1: NH₃ / methanol / 20 h / 20 °C

7.1: pyridine / 2 h / 0 °C

8.1: DCC; dichloroacetic acid / toluene; dimethylsulfoxide / 20 h / 20 °C

With pyridine; dichloro-acetic acid; N,O-bis-(trimethylsilyl)-acetamide; ammonia; acetic acid; dicyclohexyl-carbodiimide; hydrazine; In methanol; 2-ethoxy-ethanol; dimethyl sulfoxide; 1,2-dichloro-ethane; toluene; acetonitrile; 3.2: Vorbrueggen reaction;
DOI:10.1021/jm000073t