1-((R)-4-benzoyl-2-methylpiperazin-1-yl)-2-[6-chloropyridin-3-yl]ethane-1,2-dione

Base Information

Chemical Name:1-((R)-4-benzoyl-2-methylpiperazin-1-yl)-2-[6-chloropyridin-3-yl]ethane-1,2-dione
CAS No.:948990-77-0
Molecular Formula:C₁₉H₁₈ClN₃O₃
Molecular Weight:371.823
Hs Code.:

Synonyms:1-((R)-4-benzoyl-2-methylpiperazin-1-yl)-2-[6-chloropyridin-3-yl]ethane-1,2-dione

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Chemical Property of 1-((R)-4-benzoyl-2-methylpiperazin-1-yl)-2-[6-chloropyridin-3-yl]ethane-1,2-dione

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Technology Process of 1-((R)-4-benzoyl-2-methylpiperazin-1-yl)-2-[6-chloropyridin-3-yl]ethane-1,2-dione

There total 2 articles about 1-((R)-4-benzoyl-2-methylpiperazin-1-yl)-2-[6-chloropyridin-3-yl]ethane-1,2-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 73781-91-6
6-Chloronicotinic acid methyl ester

: 474010-72-5
((R)-4-benzoyl-2-methylpiperazin-1-yl)acetonitrile

: 948990-77-0
1-((R)-4-benzoyl-2-methylpiperazin-1-yl)-2-[6-chloropyridin-3-yl]ethane-1,2-dione

Guidance literature:: 6-Chloronicotinic acid methyl ester; ((R)-4-benzoyl-2-methylpiperazin-1-yl)acetonitrile; With lithium hexamethyldisilazane; In tetrahydrofuran; at 20 ℃;

With 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; water;
DOI:10.1021/jm900330x

Reference yield: 28.0%

: 948990-77-0
1-((R)-4-benzoyl-2-methylpiperazin-1-yl)-2-[6-chloropyridin-3-yl]ethane-1,2-dione

Guidance literature:

Reference yield:

: 1239363-47-3
1H-pyrazol-3-yl boronic acid

: 948990-77-0
1-((R)-4-benzoyl-2-methylpiperazin-1-yl)-2-[6-chloropyridin-3-yl]ethane-1,2-dione

: 1-((R)-4-benzoyl-2-methylpiperazin-1-yl)-2-[6-(1H-pyrazol-3-yl)pyridin-3-yl]ethane-1,2-dione

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutylammomium bromide; sodium carbonate; In ethanol; toluene; for 16h; Reflux; Inert atmosphere;
DOI:10.1021/jm900330x