1H-Pyrazol-3-ylboronic acid

Base Information

• Chemical Name: 1H-Pyrazol-3-ylboronic acid
• CAS No.: 1239363-47-3
• Molecular Formula: C3H5BN2O2
• Molecular Weight: 111.896
• Mol file: 1239363-47-3.mol

Synonyms:Pyrazol-3-ylboronic acid;3-Pyrazolylboronic acid;1H-Pyrazol-5-ylboronic acid;Boronic acid, 1H-pyrazol-3-yl- (9CI);1H-pyrazol-3-ylboronic acid;

Chemical Property of 1H-Pyrazol-3-ylboronic acid

Chemical Property:

• PSA: 69.14000
• LogP: -1.91050

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrazol-3-ylboronic acid

There total 3 articles about 1H-Pyrazol-3-ylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole (449758-17-2) → 1H-pyrazole-5-boronic acid (376584-63-3,1239363-47-3)

Guidance literature:

With n-butyllithium; triisopropylborane; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 5h;

Reference yield:

Trimethyl borate (121-43-7,63156-11-6) + C3H3BrMgN2 → 1H-pyrazole-5-boronic acid (376584-63-3,1239363-47-3)

Guidance literature:

at 10 - 20 ℃; for 0.5h;

Reference yield:

→ 1H-pyrazol-3-yl boronic acid (1239363-47-3)

Guidance literature:

upstream raw materials:

1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole

Trimethyl borate

Downstream raw materials:

[2-(1H-pyrazol-3-yl)benzyl]carbamic acid tert-butyl ester

5-phenyl-1H-pyrazole

4-methyl-2-(2H-pyrazol-3-yl)-thiazole-5-carboxylic acid benzylamide

N-(4-fluoro-2-(1H-pyrazol-5-yl)benzyl)-3-(benzyloxy)-9,9-dimethyl-4-oxo-4,6,7,9-tetrahydropyrimido[2,1-c][1,4]oxazine-2-carboxamide