Methanesulfonic acid (S)-1-{2-[(8S,10R)-10-propyl-9-(toluene-4-sulfonyl)-1,5-dithia-9-aza-spiro[5.5]undec-8-yl]-ethyl}-pentyl ester

Base Information

Chemical Name:Methanesulfonic acid (S)-1-{2-[(8S,10R)-10-propyl-9-(toluene-4-sulfonyl)-1,5-dithia-9-aza-spiro[5.5]undec-8-yl]-ethyl}-pentyl ester
CAS No.:880135-65-9
Molecular Formula:C₂₆H₄₃NO₅S₄
Molecular Weight:577.895
Hs Code.:

Synonyms:Methanesulfonic acid (S)-1-{2-[(8S,10R)-10-propyl-9-(toluene-4-sulfonyl)-1,5-dithia-9-aza-spiro[5.5]undec-8-yl]-ethyl}-pentyl ester

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Chemical Property of Methanesulfonic acid (S)-1-{2-[(8S,10R)-10-propyl-9-(toluene-4-sulfonyl)-1,5-dithia-9-aza-spiro[5.5]undec-8-yl]-ethyl}-pentyl ester

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Technology Process of Methanesulfonic acid (S)-1-{2-[(8S,10R)-10-propyl-9-(toluene-4-sulfonyl)-1,5-dithia-9-aza-spiro[5.5]undec-8-yl]-ethyl}-pentyl ester

There total 12 articles about Methanesulfonic acid (S)-1-{2-[(8S,10R)-10-propyl-9-(toluene-4-sulfonyl)-1,5-dithia-9-aza-spiro[5.5]undec-8-yl]-ethyl}-pentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2100-17-6
4-pentenal

: 880135-65-9
Methanesulfonic acid (S)-1-{2-[(8S,10R)-10-propyl-9-(toluene-4-sulfonyl)-1,5-dithia-9-aza-spiro[5.5]undec-8-yl]-ethyl}-pentyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: Zn(OTf)2; triethylamine; chiral 3-TBDMSO-2-(dimethylamino)-1-(4-nitrophenyl)propanol / toluene / 0.25 h / 20 °C

1.2: 83 percent / toluene / 12 h

2.1: 98 percent / 2,6-lutidine / CH₂Cl₂ / 1 h

3.1: 78 percent / m-CPBA / CH₂Cl₂ / 3.5 h / 20 °C

4.1: 92 percent / H₂ / Pd/C / ethyl acetate / 2 h / 760 Torr

5.1: 49 percent / AcOH; H₂O / chiral salen cobalt(II) complex / tetrahydrofuran / 0 - 20 °C

6.1: t-BuLi / diethyl ether / 1 h / -78 - -45 °C

6.2: diethyl ether / 5 h / -78 - -25 °C

6.3: 56 percent / hexamethylphosphoramide / diethyl ether / -78 - 0 °C

7.1: 98 percent / tetrabutylammonium fluoride / tetrahydrofuran / 36 h / 20 °C

8.1: triethylamine / tetrahydrofuran / 0 - 20 °C

9.1: 0.058 g / K₂CO₃ / methanol / 3 h / 20 °C

With 2,6-dimethylpyridine; chiral 3-TBDMSO-2-(dimethylamino)-1-(4-nitrophenyl)propanol; tetrabutyl ammonium fluoride; water; hydrogen; tert.-butyl lithium; zinc trifluoromethanesulfonate; potassium carbonate; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; chiral salen cobalt(II); In tetrahydrofuran; methanol; diethyl ether; dichloromethane; ethyl acetate; toluene;
DOI:10.1021/jo052314g

Reference yield:

: 692730-51-1
(R)-Non-1-en-6-yn-5-ol

: 880135-65-9
Methanesulfonic acid (S)-1-{2-[(8S,10R)-10-propyl-9-(toluene-4-sulfonyl)-1,5-dithia-9-aza-spiro[5.5]undec-8-yl]-ethyl}-pentyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: 98 percent / 2,6-lutidine / CH₂Cl₂ / 1 h

2.1: 78 percent / m-CPBA / CH₂Cl₂ / 3.5 h / 20 °C

3.1: 92 percent / H₂ / Pd/C / ethyl acetate / 2 h / 760 Torr

4.1: 49 percent / AcOH; H₂O / chiral salen cobalt(II) complex / tetrahydrofuran / 0 - 20 °C

5.1: t-BuLi / diethyl ether / 1 h / -78 - -45 °C

5.2: diethyl ether / 5 h / -78 - -25 °C

5.3: 56 percent / hexamethylphosphoramide / diethyl ether / -78 - 0 °C

6.1: 98 percent / tetrabutylammonium fluoride / tetrahydrofuran / 36 h / 20 °C

7.1: triethylamine / tetrahydrofuran / 0 - 20 °C

8.1: 0.058 g / K₂CO₃ / methanol / 3 h / 20 °C

With 2,6-dimethylpyridine; tetrabutyl ammonium fluoride; water; hydrogen; tert.-butyl lithium; potassium carbonate; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; chiral salen cobalt(II); In tetrahydrofuran; methanol; diethyl ether; dichloromethane; ethyl acetate;
DOI:10.1021/jo052314g

Reference yield:

: 692730-63-5
tert-butyl-dimethyl-[1-(2-oxiranyl-ethyl)-pentyloxy]-silane

: 880135-65-9
Methanesulfonic acid (S)-1-{2-[(8S,10R)-10-propyl-9-(toluene-4-sulfonyl)-1,5-dithia-9-aza-spiro[5.5]undec-8-yl]-ethyl}-pentyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 49 percent / AcOH; H₂O / chiral salen cobalt(II) complex / tetrahydrofuran / 0 - 20 °C

2.1: t-BuLi / diethyl ether / 1 h / -78 - -45 °C

2.2: diethyl ether / 5 h / -78 - -25 °C

2.3: 56 percent / hexamethylphosphoramide / diethyl ether / -78 - 0 °C

3.1: 98 percent / tetrabutylammonium fluoride / tetrahydrofuran / 36 h / 20 °C

4.1: triethylamine / tetrahydrofuran / 0 - 20 °C

5.1: 0.058 g / K₂CO₃ / methanol / 3 h / 20 °C

With tetrabutyl ammonium fluoride; water; tert.-butyl lithium; potassium carbonate; acetic acid; triethylamine; chiral salen cobalt(II); In tetrahydrofuran; methanol; diethyl ether;
DOI:10.1021/jo052314g