(+)-N-<(αS)-2-<<(4R,5R)-4,5-bis(2-methoxypropan-2-yl)-1,3-dioxolan-2-yl>methyl>benzhydryl>-4-methylbenzenesulfonamide

Base Information

• Chemical Name: (+)-N-<(αS)-2-<<(4R,5R)-4,5-bis(2-methoxypropan-2-yl)-1,3-dioxolan-2-yl>methyl>benzhydryl>-4-methylbenzenesulfonamide
• CAS No.: 213686-67-0
• Molecular Formula: C₃₂H₄₁NO₆S
• Molecular Weight: 567.747
• Mol file: 213686-67-0.mol

Synonyms:(+)-N-<(αS)-2-<<(4R,5R)-4,5-bis(2-methoxypropan-2-yl)-1,3-dioxolan-2-yl>methyl>benzhydryl>-4-methylbenzenesulfonamide

Chemical Property of (+)-N-<(αS)-2-<<(4R,5R)-4,5-bis(2-methoxypropan-2-yl)-1,3-dioxolan-2-yl>methyl>benzhydryl>-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+)-N-<(αS)-2-<<(4R,5R)-4,5-bis(2-methoxypropan-2-yl)-1,3-dioxolan-2-yl>methyl>benzhydryl>-4-methylbenzenesulfonamide

There total 4 articles about (+)-N-<(αS)-2-<<(4R,5R)-4,5-bis(2-methoxypropan-2-yl)-1,3-dioxolan-2-yl>methyl>benzhydryl>-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenyl N-tosyl imine (51608-60-7) + (4R,5R)-2-(2-Bromo-benzyl)-4,5-bis-(1-methoxy-1-methyl-ethyl)-[1,3]dioxolane (172794-67-1) → (-)-N-<(αR)-2-<<(4R,5R)-4,5-bis(2-methoxypropan-2-yl)-1,3-dioxolan-2-yl>methyl>benzhydryl>-4-methylbenzenesulfonamide (213595-50-7) + (+)-N-<(αS)-2-<<(4R,5R)-4,5-bis(2-methoxypropan-2-yl)-1,3-dioxolan-2-yl>methyl>benzhydryl>-4-methylbenzenesulfonamide (213686-67-0)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at -100 ℃; for 4h; Yield given; Yields of byproduct given;

DOI:10.1246/cl.1998.799

Reference yield:

toluene-4-sulfonamide (70-55-3) → (+)-N-<(αS)-2-<<(4R,5R)-4,5-bis(2-methoxypropan-2-yl)-1,3-dioxolan-2-yl>methyl>benzhydryl>-4-methylbenzenesulfonamide (213686-67-0)

Guidance literature:

Multi-step reaction with 2 steps

2: n-BuLi / tetrahydrofuran / 4 h / -100 °C

With n-butyllithium; In tetrahydrofuran;

DOI:10.1246/cl.1998.799

Reference yield:

(diethoxymethyl)benzene (774-48-1) → (+)-N-<(αS)-2-<<(4R,5R)-4,5-bis(2-methoxypropan-2-yl)-1,3-dioxolan-2-yl>methyl>benzhydryl>-4-methylbenzenesulfonamide (213686-67-0)

Guidance literature:

Multi-step reaction with 2 steps

2: n-BuLi / tetrahydrofuran / 4 h / -100 °C

With n-butyllithium; In tetrahydrofuran;

DOI:10.1246/cl.1998.799

upstream raw materials:

phenyl N-tosyl imine

(4R,5R)-2-(2-Bromo-benzyl)-4,5-bis-(1-methoxy-1-methyl-ethyl)-[1,3]dioxolane

(diethoxymethyl)benzene

benzaldehyde

Downstream raw materials:

(S)-(+)-2-<<(4R,5R)-4,5-bis(2-methoxypropan-2-yl)-1,3-dioxolan-2-yl>methyl>benzhydrylamine

(2R,3R)-1,4-dimethoxy-1,1,4,4-tetramethyl-2,3-butanediol

(S)-(-)-2-(4-methylphenylsulfonyl)-1-phenyl-1,2-dihydroisoquinoline

(S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline