N-{3-[(2-amino[1,2,4]triazolo[1,5-a]pyridin-6-yl)oxy]-5-methylphenyl}-1,3-dimethyl-1H-pyrazole-5-carboxamide

Base Information

Chemical Name:N-{3-[(2-amino[1,2,4]triazolo[1,5-a]pyridin-6-yl)oxy]-5-methylphenyl}-1,3-dimethyl-1H-pyrazole-5-carboxamide
CAS No.:1092394-70-1
Molecular Formula:C₁₉H₁₉N₇O₂
Molecular Weight:377.406
Hs Code.:

Synonyms:N-{3-[(2-amino[1,2,4]triazolo[1,5-a]pyridin-6-yl)oxy]-5-methylphenyl}-1,3-dimethyl-1H-pyrazole-5-carboxamide

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Chemical Property of N-{3-[(2-amino[1,2,4]triazolo[1,5-a]pyridin-6-yl)oxy]-5-methylphenyl}-1,3-dimethyl-1H-pyrazole-5-carboxamide

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Technology Process of N-{3-[(2-amino[1,2,4]triazolo[1,5-a]pyridin-6-yl)oxy]-5-methylphenyl}-1,3-dimethyl-1H-pyrazole-5-carboxamide

There total 6 articles about N-{3-[(2-amino[1,2,4]triazolo[1,5-a]pyridin-6-yl)oxy]-5-methylphenyl}-1,3-dimethyl-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1092394-18-7
ethyl ({[5-(3-{[(1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]amino}-5-methylphenoxy)pyridin-2-yl]amino}carbonothioyl)carbamate

: 1092394-70-1
N-{3-[(2-amino[1,2,4]triazolo[1,5-a]pyridin-6-yl)oxy]-5-methylphenyl}-1,3-dimethyl-1H-pyrazole-5-carboxamide

Guidance literature:: With hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; at 80 ℃; for 14h;

Reference yield:

: 1092394-07-4
N-{3-[(6-aminopyridin-3-yl)oxy]-5-methylphenyl}-1,3-dimethyl-1H-pyrazole-5-carboxamide

: 1092394-70-1
N-{3-[(2-amino[1,2,4]triazolo[1,5-a]pyridin-6-yl)oxy]-5-methylphenyl}-1,3-dimethyl-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: dimethyl sulfoxide / 15 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; hydroxylamine hydrochloride / ethanol; methanol

With hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; dimethyl sulfoxide;
DOI:10.1016/j.bmc.2013.04.042

Reference yield:

: 76619-89-1
3-amino-5-methylphenol

: 1092394-70-1
N-{3-[(2-amino[1,2,4]triazolo[1,5-a]pyridin-6-yl)oxy]-5-methylphenyl}-1,3-dimethyl-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / tetrahydrofuran / 15 h / 0 - 20 °C

2: caesium carbonate / N,N-dimethyl-formamide / 15 h / 20 °C

3: palladium on activated charcoal; hydrogen / methanol / 4 h / 20 °C

4: dimethyl sulfoxide / 15 h / 20 °C

5: N-ethyl-N,N-diisopropylamine; hydroxylamine hydrochloride / ethanol; methanol

With palladium on activated charcoal; hydroxylamine hydrochloride; hydrogen; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.04.042