76619-89-1

Basic information

• Product Name: 3-AMINO-5-METHYL PHENOL
• Synonyms: 3-AMINO-5-METHYL PHENOL;5-amino-m-cresol;3-AMino-5-Methyl Phenol HCl;Phenol, 3-aMino-5-Methyl-
• CAS NO: 76619-89-1
• Molecular Formula: C₇H₉NO
• Molecular Weight: 123.15246
• EINECS: 278-502-6
• Mol File: 76619-89-1.mol
• Article Data: 4

Chemical Properties

• Melting Point: 139°C
• Boiling Point: 229.26°C (rough estimate)
• Flash Point: 123.8 °C
• Appearance: /
• Density: 1.0877 (rough estimate)
• Vapor Pressure: 0.00213mmHg at 25°C
• Refractive Index: 1.5706 (estimate)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 10.13±0.10(Predicted)
• CAS DataBase Reference: 3-AMINO-5-METHYL PHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-5-METHYL PHENOL(76619-89-1)
• EPA Substance Registry System: 3-AMINO-5-METHYL PHENOL(76619-89-1)

Safety Data

• Hazardous Substances Data: 76619-89-1(Hazardous Substances Data)

Usage

General Description

3-Amino-5-methylphenol, also known as 3-Amino-m-cresol, is an organic compound and a derivative of phenol. It is commonly used in hair dyes and colorants as a developer and intermediate to produce various shades and tones. The compound has a molecular formula of C7H9NO, and its chemical structure consists of a phenol ring with an attached amino group and a methyl group. 3-Amino-5-methylphenol is a brown crystalline solid with a slightly aromatic odor. It is considered to be a skin and eye irritant and may cause allergic reactions in some individuals. Therefore, it is important to handle this chemical with caution and use appropriate protective measures when working with it.

InChI:InChI=1/C7H9NO/c1-5-2-6(8)4-7(9)3-5/h2-4,9H,8H2,1H3

Upstream product

• 4341-24-6 5-methylcyclohexan-1,3-dione 
• 618-61-1 3-methyl-5-nitro-aniline 
• 618-85-9 3,5-dinitrotoluene 
• 127818-58-0 3-methyl-5-nitrophenol 
• 504-15-4 orcinol 

Downstream Products

• 119004-83-0 2,2,2-Trifluoro-N-(3-hydroxy-5-methyl-phenyl)-acetamide 
• 161291-74-3 2-(3-Hydroxy-5-methyl-phenyl)-isoindole-1,3-dione 
• 161620-93-5 N-(tert-butyloxy-carbonyl)-3-hydroxy-5-methyl-aniline 
• 1443134-60-8 3{1N(3-methyl-5-hydroxyphenyl)-1H-1,2,3-triazol-4yl}methyloxy betulinic acid 
• 1443134-69-7 3-azido-5-methylphenol 
• 62988-21-0 3-(ethylamino)-5-methylphenol 
• 1092391-73-5 N-[3-({2-[(cyclopropylcarbonyl)amino][1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)-5-methylphenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide 
• 1092394-70-1 N-{3-[(2-amino[1,2,4]triazolo[1,5-a]pyridin-6-yl)oxy]-5-methylphenyl}-1,3-dimethyl-1H-pyrazole-5-carboxamide 
• 1092394-07-4 N-{3-[(6-aminopyridin-3-yl)oxy]-5-methylphenyl}-1,3-dimethyl-1H-pyrazole-5-carboxamide 
• 1092394-18-7 ethyl ({[5-(3-{[(1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]amino}-5-methylphenoxy)pyridin-2-yl]amino}carbonothioyl)carbamate 
• 1092394-05-2 N-(3-hydroxy-5-methylphenyl)-1,3-dimethyl-1H-pyrazole-5-carboxamide 
• 932707-08-9 3-(4-chlorobenzyl)-2,4,7-trimethylquinolin-5-ol 

Relevant articles and documents

Synthesis of Substituted Anilines from Cyclohexanones Using Pd/C-Ethylene System and Its Application to Indole Synthesis

The synthesis of anilines and indoles from cyclohexanones using a Pd/C-ethylene system is reported. A simple combination of NH4OAc and K2CO3 under nonaerobic conditions was found to be the most suitable to perform this reaction. Hydrogen transfer between cyclohexanone and ethylene generates the desired products. The reaction tolerates a variety of substitutions on the starting cyclohexanones.

QUINOLINES AND THEIR THERAPEUTIC USE

Compounds of formula [1] are CRTH2 antagonists, useful in the treatment of conditions having an inflammatory component; in which: R1, R2, R3, R4 and R5 are independently hydrogen, C1-C6alkyl, C1- C6fluoroalkyl, cyclopropyl, halo, -S(O)nR6, -SO2NR7R8, -NR7R8, -NR7C(O)R6, -CO2R7, -C(O)NR7R8, -C(O)R6, -NO2, -CN or a group -OR9; wherein each R6 is independently C1-C6alkyl, C1-C6fluoroalkyl, cycloalkyl, aryl, or heteroaryl; R7, R8 are independently C1-C6alkyl, C1-C6fluoroalkyl, cycloalkyl, cycloalkyl-(C1-C6alkyl)-, aryl, heteroaryl or hydrogen; R9 is hydrogen, C1-C6alkyl, C1-C6fluoroalkyl, cycloalkyl, cylcoalkyl-(C1-C6alkyl)-, or a group -SO2R6; A is -CHR10-, -C(O)-, -S(O)n-, -0-, or -NR10- wherein n is an integer from 0-2 and R10 is hydrogen, C1-C3alkyl, or C1-C6fluoroalkyl group; B is a direct bond, or a divalent radical selected from -CH2-, -CH2CH2-, -CHR11-, -CR11R12-, -CH2CHR11-, -CH2CR11R12-, -CHR11CHR12-, and divalent radicals of formula -(CR11R12)P-Z- wherein Z is attached to the ring carrying R1, R2 and R3; wherein R11 is C1-C3alkyl, cyclopropyl, C1-C6fluoroalkyl; R12 is methyl or fluoromethyl; p is independently 1 or 2; and Z is -0-, -NH-, or -S(O)n-, wherein n is an integer from 0-2; X is a carboxylic acid, tetrazole, 3-hydroxyisoxazole, hydroxamic acid, phosphinate, phosphonate, phosphonamide, or sulfonic acid group, or a group of formula C(=O)NHSO2R6or SO2NHC(=O)R6; and Y is aryl, heteroaryl, aryl-fused- heterocycloalkyl, heteroaryl-fused-cycloalkyl, heteroaryl-fused-heterocycloalkyl or aryl-fused-cycloalkyl group.