(S)-methyl 2-((tert-butoxycarbonyl)amino)-3-(4-(2-(4-(heptyloxy)phenyl)thiazol-4-yl)phenyl)propanoate

Base Information

• Chemical Name: (S)-methyl 2-((tert-butoxycarbonyl)amino)-3-(4-(2-(4-(heptyloxy)phenyl)thiazol-4-yl)phenyl)propanoate
• CAS No.: 1443792-00-4
• Molecular Formula: C₃₁H₄₀N₂O₅S
• Molecular Weight: 552.735
• Mol file: 1443792-00-4.mol

Synonyms:(S)-methyl 2-((tert-butoxycarbonyl)amino)-3-(4-(2-(4-(heptyloxy)phenyl)thiazol-4-yl)phenyl)propanoate

Chemical Property of (S)-methyl 2-((tert-butoxycarbonyl)amino)-3-(4-(2-(4-(heptyloxy)phenyl)thiazol-4-yl)phenyl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-methyl 2-((tert-butoxycarbonyl)amino)-3-(4-(2-(4-(heptyloxy)phenyl)thiazol-4-yl)phenyl)propanoate

There total 5 articles about (S)-methyl 2-((tert-butoxycarbonyl)amino)-3-(4-(2-(4-(heptyloxy)phenyl)thiazol-4-yl)phenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

4-(4-bromophenyl)-2-(4-(heptyloxy)phenyl)thiazole (1443791-99-8) + N-(tert-butoxycarbonyl)-L-3-iodoalanine methyl ester (93267-04-0,170848-34-7,889670-02-4) → (S)-methyl 2-((tert-butoxycarbonyl)amino)-3-(4-(2-(4-(heptyloxy)phenyl)thiazol-4-yl)phenyl)propanoate (1443792-00-4)

Guidance literature:

N-(tert-butoxycarbonyl)-L-3-iodoalanine methyl ester; With iodine; zinc; In N,N-dimethyl-formamide; for 0.5h;

4-(4-bromophenyl)-2-(4-(heptyloxy)phenyl)thiazole; With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In N,N-dimethyl-formamide; at 50 ℃; for 3h; Inert atmosphere;

Reference yield:

4-(heptyloxy)benzothioamide (77477-92-0) → (S)-methyl 2-((tert-butoxycarbonyl)amino)-3-(4-(2-(4-(heptyloxy)phenyl)thiazol-4-yl)phenyl)propanoate (1443792-00-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: isopropyl alcohol

2.1: zinc; iodine / N,N-dimethyl-formamide / 0.5 h

2.2: 3 h / 50 °C / Inert atmosphere

With iodine; zinc; In N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

4-(heptyloxy)benzamide (203116-01-2) → (S)-methyl 2-((tert-butoxycarbonyl)amino)-3-(4-(2-(4-(heptyloxy)phenyl)thiazol-4-yl)phenyl)propanoate (1443792-00-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 2,4-(4-phenoxyphenyl)-1,3-dithia-2λ(5),4λ(5)-diphosphetane 2,4-disulfides / tetrahydrofuran; 1,2-dimethoxyethane / 16 h / 20 °C

2.1: isopropyl alcohol

3.1: zinc; iodine / N,N-dimethyl-formamide / 0.5 h

3.2: 3 h / 50 °C / Inert atmosphere

With iodine; 2,4-(4-phenoxyphenyl)-1,3-dithia-2λ(5),4λ(5)-diphosphetane 2,4-disulfides; zinc; In tetrahydrofuran; 1,2-dimethoxyethane; N,N-dimethyl-formamide; isopropyl alcohol;

upstream raw materials:

4-(4-bromophenyl)-2-(4-(heptyloxy)phenyl)thiazole

N-(tert-butoxycarbonyl)-L-3-iodoalanine methyl ester

4-(heptyloxy)benzothioamide

4-n-heptyloxybromobenzene