N-phenoxyacetyl-7-O-(tert-butyldiphenylsilyl)-N-trityl morpholinocytidine

Base Information

Chemical Name:N-phenoxyacetyl-7-O-(tert-butyldiphenylsilyl)-N-trityl morpholinocytidine
CAS No.:1415645-63-4
Molecular Formula:C₅₂H₅₂N₄O₅Si
Molecular Weight:841.094
Hs Code.:

Synonyms:N-phenoxyacetyl-7-O-(tert-butyldiphenylsilyl)-N-trityl morpholinocytidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-phenoxyacetyl-7-O-(tert-butyldiphenylsilyl)-N-trityl morpholinocytidine

Chemical Property:

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Technology Process of N-phenoxyacetyl-7-O-(tert-butyldiphenylsilyl)-N-trityl morpholinocytidine

There total 4 articles about N-phenoxyacetyl-7-O-(tert-butyldiphenylsilyl)-N-trityl morpholinocytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1415645-56-5
7-O-(tert-butyldiphenylsilyl)-N-trityl morpholinocytidine

: 122-59-8
2-phenoxyacetic acid

: 1415645-63-4
N-phenoxyacetyl-7-O-(tert-butyldiphenylsilyl)-N-trityl morpholinocytidine

Guidance literature:: With oxalyl dichloride; In N,N-dimethyl-formamide; toluene; at 0 - 20 ℃; Molecular sieve; Inert atmosphere;
DOI:10.1080/15257770.2012.724491

Reference yield:

: 1415645-50-9
7-O-(tert-butyldiphenylsilyl)morpholinocytidine

: 1415645-63-4
N-phenoxyacetyl-7-O-(tert-butyldiphenylsilyl)-N-trityl morpholinocytidine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / N,N-dimethyl-formamide / 1 h / 0 °C / Molecular sieve; Inert atmosphere

2: oxalyl dichloride / N,N-dimethyl-formamide; toluene / 0 - 20 °C / Molecular sieve; Inert atmosphere

With oxalyl dichloride; triethylamine; In N,N-dimethyl-formamide; toluene;
DOI:10.1080/15257770.2012.724491

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1415645-63-4
N-phenoxyacetyl-7-O-(tert-butyldiphenylsilyl)-N-trityl morpholinocytidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1H-imidazole / pyridine / Molecular sieve; Inert atmosphere

2.1: sodium periodate; ammonium biborate tetrahydrate / methanol / 1.5 h / 20 °C / Molecular sieve; Inert atmosphere

2.2: 2 h / Molecular sieve; Inert atmosphere

3.1: triethylamine / N,N-dimethyl-formamide / 1 h / 0 °C / Molecular sieve; Inert atmosphere

4.1: oxalyl dichloride / N,N-dimethyl-formamide; toluene / 0 - 20 °C / Molecular sieve; Inert atmosphere

With 1H-imidazole; sodium periodate; oxalyl dichloride; ammonium biborate tetrahydrate; triethylamine; In pyridine; methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1080/15257770.2012.724491