4-{allyl-[2-(3-fluoro-phenyl)-ethyl]-carbamoyl}-pent-4-enoic acid methyl ester

Base Information

Chemical Name:4-{allyl-[2-(3-fluoro-phenyl)-ethyl]-carbamoyl}-pent-4-enoic acid methyl ester
CAS No.:1415411-01-6
Molecular Formula:C₁₈H₂₂FNO₃
Molecular Weight:319.376
Hs Code.:

Synonyms:4-{allyl-[2-(3-fluoro-phenyl)-ethyl]-carbamoyl}-pent-4-enoic acid methyl ester

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Chemical Property of 4-{allyl-[2-(3-fluoro-phenyl)-ethyl]-carbamoyl}-pent-4-enoic acid methyl ester

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Technology Process of 4-{allyl-[2-(3-fluoro-phenyl)-ethyl]-carbamoyl}-pent-4-enoic acid methyl ester

There total 5 articles about 4-{allyl-[2-(3-fluoro-phenyl)-ethyl]-carbamoyl}-pent-4-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 93633-32-0
5-methoxy-2-methylene-5-oxopentanoic acid

: 1249632-08-3
C₁₁H₁₄FN

: 1415411-01-6
4-{allyl-[2-(3-fluoro-phenyl)-ethyl]-carbamoyl}-pent-4-enoic acid methyl ester

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 8h; Inert atmosphere;
DOI:10.1021/jm3009376

Reference yield: 72.0%

: 93633-32-0
5-methoxy-2-methylene-5-oxopentanoic acid

: 798543-08-5
allyl-[2-(2-fluoro-phenyl)-ethyl]-amine

: 1415411-01-6
4-{allyl-[2-(3-fluoro-phenyl)-ethyl]-carbamoyl}-pent-4-enoic acid methyl ester

Guidance literature:: With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 20 ℃; for 10h;

Reference yield:

: 5621-44-3
dimethyl 2-methylenepentanedioate

: 1415411-01-6
4-{allyl-[2-(3-fluoro-phenyl)-ethyl]-carbamoyl}-pent-4-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: camphor-10-sulfonic acid / methanol / 2.5 h / 20 °C

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / Inert atmosphere

With dmap; camphor-10-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane;
DOI:10.1002/cmdc.201300393