(S)-1-(4,5-dichloro-2-(3-methoxypropyl)phenyl)-3-(4-methyl-3-(morpholin-2-ylmethoxy)-1-phenyl-1H-pyrazol-5-yl)urea hydrochloride

Base Information

Chemical Name:(S)-1-(4,5-dichloro-2-(3-methoxypropyl)phenyl)-3-(4-methyl-3-(morpholin-2-ylmethoxy)-1-phenyl-1H-pyrazol-5-yl)urea hydrochloride
CAS No.:1610454-84-6
Molecular Formula:C₂₆H₃₁Cl₂N₅O₄*ClH
Molecular Weight:584.93
Hs Code.:

Synonyms:(S)-1-(4,5-dichloro-2-(3-methoxypropyl)phenyl)-3-(4-methyl-3-(morpholin-2-ylmethoxy)-1-phenyl-1H-pyrazol-5-yl)urea hydrochloride

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Chemical Property of (S)-1-(4,5-dichloro-2-(3-methoxypropyl)phenyl)-3-(4-methyl-3-(morpholin-2-ylmethoxy)-1-phenyl-1H-pyrazol-5-yl)urea hydrochloride

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Technology Process of (S)-1-(4,5-dichloro-2-(3-methoxypropyl)phenyl)-3-(4-methyl-3-(morpholin-2-ylmethoxy)-1-phenyl-1H-pyrazol-5-yl)urea hydrochloride

There total 7 articles about (S)-1-(4,5-dichloro-2-(3-methoxypropyl)phenyl)-3-(4-methyl-3-(morpholin-2-ylmethoxy)-1-phenyl-1H-pyrazol-5-yl)urea hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1610455-38-3
(S)-tert-butyl 2-(((5-(3-(4,5-dichloro-2-(3-methoxypropyl)phenyl)ureido)-4-methyl-1-phenyl-1H-pyrazol-3-yl)oxy)methyl)morpholine-4-carboxylate

: 1610454-84-6
(S)-1-(4,5-dichloro-2-(3-methoxypropyl)phenyl)-3-(4-methyl-3-(morpholin-2-ylmethoxy)-1-phenyl-1H-pyrazol-5-yl)urea hydrochloride

Guidance literature:: With hydrogenchloride; In isopropyl alcohol; at 20 ℃; for 2h;

Reference yield:

: 25173-68-6
3(3,4-dichlorophenyl)propanoic acid

: 1610454-84-6
(S)-1-(4,5-dichloro-2-(3-methoxypropyl)phenyl)-3-(4-methyl-3-(morpholin-2-ylmethoxy)-1-phenyl-1H-pyrazol-5-yl)urea hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: borane-THF / tetrahydrofuran / 17.33 h / 20 °C / Reflux

2.1: sodium hydride / tetrahydrofuran / 0.25 h / 20 °C

2.2: 15 h

3.1: nitronium tetrafluoborate / dichloromethane / 4 h / -15 - 0 °C

4.1: hydrogen / water; methanol / 20 h

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3.5 h

6.1: 1,4-dioxane / 24 h / 20 °C

7.1: hydrogenchloride / isopropyl alcohol / 2 h / 20 °C

With hydrogenchloride; nitronium tetrafluoborate; borane-THF; hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; isopropyl alcohol;

Reference yield:

: 39960-05-9
3-(3 ,4-dichlorophenyl)propan-1-ol

: 1610454-84-6
(S)-1-(4,5-dichloro-2-(3-methoxypropyl)phenyl)-3-(4-methyl-3-(morpholin-2-ylmethoxy)-1-phenyl-1H-pyrazol-5-yl)urea hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran / 0.25 h / 20 °C

1.2: 15 h

2.1: nitronium tetrafluoborate / dichloromethane / 4 h / -15 - 0 °C

3.1: hydrogen / water; methanol / 20 h

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3.5 h

5.1: 1,4-dioxane / 24 h / 20 °C

6.1: hydrogenchloride / isopropyl alcohol / 2 h / 20 °C

With hydrogenchloride; nitronium tetrafluoborate; hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; isopropyl alcohol;