N-(2-(2-chloro-5-(dimethylamino)phenylamino)-4'-methyl-4,5'-bithiazol-2'-yl)-4-fluorobenzamide

Base Information

• Chemical Name: N-(2-(2-chloro-5-(dimethylamino)phenylamino)-4'-methyl-4,5'-bithiazol-2'-yl)-4-fluorobenzamide
• CAS No.: 1361409-69-9
• Molecular Formula: C₂₂H₁₉ClFN₅OS₂
• Molecular Weight: 488.009

Synonyms:N-(2-(2-chloro-5-(dimethylamino)phenylamino)-4'-methyl-4,5'-bithiazol-2'-yl)-4-fluorobenzamide

Chemical Property of N-(2-(2-chloro-5-(dimethylamino)phenylamino)-4'-methyl-4,5'-bithiazol-2'-yl)-4-fluorobenzamide

Chemical Property:

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Technology Process of N-(2-(2-chloro-5-(dimethylamino)phenylamino)-4'-methyl-4,5'-bithiazol-2'-yl)-4-fluorobenzamide

There total 5 articles about N-(2-(2-chloro-5-(dimethylamino)phenylamino)-4'-methyl-4,5'-bithiazol-2'-yl)-4-fluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N(2)-(2-chloro-5-(dimethylamino)phenyl)-4'-methyl-[4,5'-bithiazole]-2,2'-diamine (1350650-02-0) + 4-fluorobenzoyl chloride (403-43-0) → N-(2-(2-chloro-5-(dimethylamino)phenylamino)-4'-methyl-4,5'-bithiazol-2'-yl)-4-fluorobenzamide (1361409-69-9)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmcl.2011.12.128

Reference yield:

1-(2-amino-4-methylthiazol-5-yl)-2-bromoethanone (32519-72-5) → N-(2-(2-chloro-5-(dimethylamino)phenylamino)-4'-methyl-4,5'-bithiazol-2'-yl)-4-fluorobenzamide (1361409-69-9)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / Reflux

2: triethylamine / dichloromethane / 20 °C / Inert atmosphere

With triethylamine; In ethanol; dichloromethane;

DOI:10.1016/j.bmcl.2011.12.128

Reference yield:

5-acetyl-4-methylthiazole-2-amine (30748-47-1) → N-(2-(2-chloro-5-(dimethylamino)phenylamino)-4'-methyl-4,5'-bithiazol-2'-yl)-4-fluorobenzamide (1361409-69-9)

Guidance literature:

Multi-step reaction with 3 steps

1: bromine; acetic acid

2: ethanol / Reflux

3: triethylamine / dichloromethane / 20 °C / Inert atmosphere

With bromine; acetic acid; triethylamine; In ethanol; dichloromethane;

DOI:10.1016/j.bmcl.2011.12.128

upstream raw materials:

1-(2-amino-4-methylthiazol-5-yl)-2-bromoethanone

5-acetyl-4-methylthiazole-2-amine

N⁽²⁾-(2-chloro-5-(dimethylamino)phenyl)-4'-methyl-[4,5'-bithiazole]-2,2'-diamine

4-fluorobenzoyl chloride

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