Oxirane, 2-(2-fluorophenyl)-3-methyl- (9CI)

Base Information

• Chemical Name: Oxirane, 2-(2-fluorophenyl)-3-methyl- (9CI)
• CAS No.: 234115-65-2
• Molecular Formula: C₉H₉FO
• Molecular Weight: 152.168
• Mol file: 234115-65-2.mol

Synonyms:Oxirane, 2-(2-fluorophenyl)-3-methyl- (9CI)

Chemical Property of Oxirane, 2-(2-fluorophenyl)-3-methyl- (9CI)

Chemical Property:

• PSA: 12.53000
• LogP: 2.28550

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Oxirane, 2-(2-fluorophenyl)-3-methyl- (9CI)

There total 4 articles about Oxirane, 2-(2-fluorophenyl)-3-methyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

β-methyl-2-fluorostyrene → 2-(2-fluorophenyl)-3-methyloxirane (234115-65-2)

Guidance literature:

With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 1.33333h; Schlenk technique; Inert atmosphere;

DOI:10.1002/anie.202002844

Reference yield:

(2-fluorophenyl)acetylene (766-49-4) → cis-2-fluoro-beta-methylstyrene oxide (234115-65-2)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydride / 1,4-dioxane

2: hydrogen / hexane

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane

With hydrogen; sodium hydride; 3-chloro-benzenecarboperoxoic acid; In 1,4-dioxane; hexane; dichloromethane;

DOI:10.1002/cjoc.202100252

Reference yield:

β-methyl-2-fluorostyrene → cis-2-fluoro-beta-methylstyrene oxide (234115-65-2)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

DOI:10.1002/cjoc.202100252

upstream raw materials:

(2-fluorophenyl)acetylene

Refernces

• 1、 Beller, Matthias,Junge, Kathrin,Leischner, Thomas,Li, Wu,Liu, Weiping. "A General Regioselective Synthesis of Alcohols by Cobalt-Catalyzed Hydrogenation of Epoxides". supporting information. p. 11321 - 11324. Retrieved 2020/05/16.