tert-butyl N-(tert-butoxycarbonyl)-N-[2-({[(5S)-3-(5-{2-fluoro-4-[(5R)-2-oxo-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-3-yl]phenyl}pyridin-2-yl)-4,5-dihydroisoxazol-5-yl]methyl}amino)-2-oxoethyl]glycinate

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Chemical Name:tert-butyl N-(tert-butoxycarbonyl)-N-[2-({[(5S)-3-(5-{2-fluoro-4-[(5R)-2-oxo-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-3-yl]phenyl}pyridin-2-yl)-4,5-dihydroisoxazol-5-yl]methyl}amino)-2-oxoethyl]glycinate
CAS No.:870893-63-3
Molecular Formula:C₃₄H₄₁FN₈O₈
Molecular Weight:708.747
Hs Code.:

tert-butyl N-(tert-butoxycarbonyl)-N-[2-({[(5S)-3-(5-{2-fluoro-4-[(5R)-2-oxo-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-3-yl]phenyl}pyridin-2-yl)-4,5-dihydroisoxazol-5-yl]methyl}amino)-2-oxoethyl]glycinate

Synonyms:tert-butyl N-(tert-butoxycarbonyl)-N-[2-({[(5S)-3-(5-{2-fluoro-4-[(5R)-2-oxo-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-3-yl]phenyl}pyridin-2-yl)-4,5-dihydroisoxazol-5-yl]methyl}amino)-2-oxoethyl]glycinate

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Chemical Property of tert-butyl N-(tert-butoxycarbonyl)-N-[2-({[(5S)-3-(5-{2-fluoro-4-[(5R)-2-oxo-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-3-yl]phenyl}pyridin-2-yl)-4,5-dihydroisoxazol-5-yl]methyl}amino)-2-oxoethyl]glycinate

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Technology Process of tert-butyl N-(tert-butoxycarbonyl)-N-[2-({[(5S)-3-(5-{2-fluoro-4-[(5R)-2-oxo-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-3-yl]phenyl}pyridin-2-yl)-4,5-dihydroisoxazol-5-yl]methyl}amino)-2-oxoethyl]glycinate

There total 19 articles about tert-butyl N-(tert-butoxycarbonyl)-N-[2-({[(5S)-3-(5-{2-fluoro-4-[(5R)-2-oxo-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-3-yl]phenyl}pyridin-2-yl)-4,5-dihydroisoxazol-5-yl]methyl}amino)-2-oxoethyl]glycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 870893-58-6
(5R)-3-(4-{6-[(5S)-5-(aminomethyl)-4,5-dihydroisoxazol-3-yl]pyridin-3-yl}-3-fluorophenyl)-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-2-one

: N-(tert-butoxycarbonyl)-N-(2-tert-butoxy-2-oxoethyl)glycine

: 870893-63-3
tert-butyl N-(tert-butoxycarbonyl)-N-[2-({[(5S)-3-(5-{2-fluoro-4-[(5R)-2-oxo-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-3-yl]phenyl}pyridin-2-yl)-4,5-dihydroisoxazol-5-yl]methyl}amino)-2-oxoethyl]glycinate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 0.5h;

Reference yield:

: acetic acid (5R)-3-(3-fluorophenyl)-2-oxooxazolidin-5-ylmethyl ester

: 870893-63-3
tert-butyl N-(tert-butoxycarbonyl)-N-[2-({[(5S)-3-(5-{2-fluoro-4-[(5R)-2-oxo-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-3-yl]phenyl}pyridin-2-yl)-4,5-dihydroisoxazol-5-yl]methyl}amino)-2-oxoethyl]glycinate

Guidance literature:: Multi-step reaction with 9 steps

1: iodine; silver trifluoroacetate / chloroform; acetonitrile / 36.5 h / 20 °C

2: methanol; potassium carbonate / dichloromethane / 0.42 h / 20 °C

3: triethylamine / dichloromethane / 0 - 20 °C

4: sodium azide / DMF (N,N-dimethyl-formamide) / 75 °C

5: 1,4-dioxane / 100 °C

6: triethylamine / trans-bis(triphenylphosphine)palladium dichloride / 1,4-dioxane / 1.5 h / 100 °C

7: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / DMF (N,N-dimethyl-formamide); water / 1 h / 85 °C

8: hydrogenchloride / 1,4-dioxane; DMF (N,N-dimethyl-formamide) / 18 h

9: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / DMF (N,N-dimethyl-formamide) / 0.5 h / 20 °C

With hydrogenchloride; methanol; dmap; sodium azide; iodine; silver trifluoroacetate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trans-bis(triphenylphosphine)palladium dichloride; In 1,4-dioxane; DMF (N,N-dimethyl-formamide); dichloromethane; chloroform; water; acetonitrile;

Reference yield:

: 501939-95-3
(5R)-3-(3-fluoro-4-iodophenyl)-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-2-one

: 870893-63-3
tert-butyl N-(tert-butoxycarbonyl)-N-[2-({[(5S)-3-(5-{2-fluoro-4-[(5R)-2-oxo-5-(1H-1,2,3-triazol-1-ylmethyl)-1,3-oxazolidin-3-yl]phenyl}pyridin-2-yl)-4,5-dihydroisoxazol-5-yl]methyl}amino)-2-oxoethyl]glycinate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / trans-bis(triphenylphosphine)palladium dichloride / 1,4-dioxane / 1.5 h / 100 °C

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / DMF (N,N-dimethyl-formamide); water / 1 h / 85 °C

3: hydrogenchloride / 1,4-dioxane; DMF (N,N-dimethyl-formamide) / 18 h

4: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / DMF (N,N-dimethyl-formamide) / 0.5 h / 20 °C

With hydrogenchloride; dmap; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trans-bis(triphenylphosphine)palladium dichloride; In 1,4-dioxane; DMF (N,N-dimethyl-formamide); water;