methyl 3α,12α-bis-<3-(4-nitrophenyl)propanoyloxy>-5β-cholan-24-oate

Base Information

• Chemical Name: methyl 3α,12α-bis-<3-(4-nitrophenyl)propanoyloxy>-5β-cholan-24-oate
• CAS No.: 162850-16-0
• Molecular Formula: C₄₃H₅₆N₂O₁₀
• Molecular Weight: 760.925
• Mol file: 162850-16-0.mol

Synonyms:methyl 3α,12α-bis-<3-(4-nitrophenyl)propanoyloxy>-5β-cholan-24-oate

Chemical Property of methyl 3α,12α-bis-<3-(4-nitrophenyl)propanoyloxy>-5β-cholan-24-oate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3α,12α-bis-<3-(4-nitrophenyl)propanoyloxy>-5β-cholan-24-oate

There total 2 articles about methyl 3α,12α-bis-<3-(4-nitrophenyl)propanoyloxy>-5β-cholan-24-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

methyl deoxycholate (3245-38-3) + 3-(p-nitrophenyl)propanoyl chloride (107324-93-6) → methyl 3α,12α-bis-<3-(4-nitrophenyl)propanoyloxy>-5β-cholan-24-oate (162850-16-0)

Guidance literature:

With calcium hydride; N-benzyl-N,N,N-triethylammonium chloride; In toluene; at 90 ℃; for 20h;

Reference yield:

3-(4-nitrophenyl)propionic acid (16642-79-8) → methyl 3α,12α-bis-<3-(4-nitrophenyl)propanoyloxy>-5β-cholan-24-oate (162850-16-0)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl dichloride / 12.25 h / 47 - 57 °C

2: 1.07 g / CaH₂, benzyltriethylammonium chloride / toluene / 7 h / 86 - 93 °C

With thionyl chloride; calcium hydride; N-benzyl-N,N,N-triethylammonium chloride; In toluene;

Reference yield: 85.4%

methyl 3α,12α-bis-<3-(4-nitrophenyl)propanoyloxy>-5β-cholan-24-oate (162850-16-0) → methyl 3α,12α-bis<3-(4-aminophenyl)propanoyloxy>-5β-cholan-24-oate (162850-17-1)

Guidance literature:

With tin(ll) chloride; In ethyl acetate; at 60 ℃; for 2h;

upstream raw materials:

methyl deoxycholate

3-(p-nitrophenyl)propanoyl chloride

3-(4-nitrophenyl)propionic acid

Downstream raw materials:

methyl 3α,12α-bis<3-(4-aminophenyl)propanoyloxy>-5β-cholan-24-oate

methyl 3α,12α-bis<3-(4-N-tosylaminophenyl)propanoyloxy>-5β-cholan-24-oate