(6R)-2-chlorophenyl 6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-4-(2,4,6-trimethoxybenzyl)-1,4-diazepan-1-carboxylate

Base Information

Chemical Name:(6R)-2-chlorophenyl 6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-4-(2,4,6-trimethoxybenzyl)-1,4-diazepan-1-carboxylate
CAS No.:889857-43-6
Molecular Formula:C₃₀H₃₀Cl₂N₂O₈
Molecular Weight:617.483
Hs Code.:

Synonyms:(6R)-2-chlorophenyl 6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-4-(2,4,6-trimethoxybenzyl)-1,4-diazepan-1-carboxylate

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Chemical Property of (6R)-2-chlorophenyl 6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-4-(2,4,6-trimethoxybenzyl)-1,4-diazepan-1-carboxylate

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Technology Process of (6R)-2-chlorophenyl 6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-4-(2,4,6-trimethoxybenzyl)-1,4-diazepan-1-carboxylate

There total 19 articles about (6R)-2-chlorophenyl 6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-4-(2,4,6-trimethoxybenzyl)-1,4-diazepan-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 889857-40-3
(6R)-6-(5-chloro-2-methoxybenzyl)-1-(2,4,6-trimethoxybenzyl)-1,4-diazepan-2,5-dione

: 19358-41-9
2-chlorophenyl chloroformate

: 889857-43-6
(6R)-2-chlorophenyl 6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-4-(2,4,6-trimethoxybenzyl)-1,4-diazepan-1-carboxylate

Guidance literature:: (6R)-6-(5-chloro-2-methoxybenzyl)-1-(2,4,6-trimethoxybenzyl)-1,4-diazepan-2,5-dione; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.333333h;

2-chlorophenyl chloroformate; In tetrahydrofuran; at -78 ℃; for 1h; Further stages.;
DOI:10.1016/j.bmcl.2007.03.085

Reference yield:

: 889855-59-8
(2E)-2-{[(tert-butoxycarbonyl)amino]methyl}-3-(5-chloro-2-methoxyphenyl)-2-propenoic acid

: 889857-43-6
(6R)-2-chlorophenyl 6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-4-(2,4,6-trimethoxybenzyl)-1,4-diazepan-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: HCl / ethyl acetate / 0.67 h / 20 °C

2.1: NaBH(OAc)3 / tetrahydrofuran / 1.5 h / 20 °C

3.1: aq. NaOH / methanol / 2.5 h / 60 °C

4.1: EDCI*HCl; HOBt; Et₃N / dimethylformamide; CH₂Cl₂ / 18 h / 20 °C

5.1: H₂ / Pt(sulfided)/C / tetrahydrofuran / 18 h / 20 °C

6.1: n-BuLi / tetrahydrofuran / 0.33 h / -78 °C

6.2: tetrahydrofuran / 1 h / -78 °C

With hydrogenchloride; sodium hydroxide; n-butyllithium; hydrogen; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; Pt(sulfided)/C; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2007.03.085

Reference yield:

: 889857-37-8
(6E)-6-(5-chloro-2-methoxybenzylidene)-1-(2,4,6-trimethoxybenzyl)-1,4-diazepan-2,5-dione

: 889857-43-6
(6R)-2-chlorophenyl 6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-4-(2,4,6-trimethoxybenzyl)-1,4-diazepan-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: H₂ / Pt(sulfided)/C / tetrahydrofuran / 18 h / 20 °C

2.1: n-BuLi / tetrahydrofuran / 0.33 h / -78 °C

2.2: tetrahydrofuran / 1 h / -78 °C

With n-butyllithium; hydrogen; Pt(sulfided)/C; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2007.03.085