(6R)-2-chlorophenyl 6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-carboxylate

Base Information

Chemical Name:(6R)-2-chlorophenyl 6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-carboxylate
CAS No.:1312770-62-9
Molecular Formula:C₂₀H₁₈Cl₂N₂O₅
Molecular Weight:437.279
Hs Code.:

Synonyms:(6R)-2-chlorophenyl 6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-carboxylate

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Chemical Property of (6R)-2-chlorophenyl 6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-carboxylate

Chemical Property:

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Technology Process of (6R)-2-chlorophenyl 6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-carboxylate

There total 16 articles about (6R)-2-chlorophenyl 6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 889857-43-6
(6R)-2-chlorophenyl 6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-4-(2,4,6-trimethoxybenzyl)-1,4-diazepan-1-carboxylate

: 1312770-62-9
(6R)-2-chlorophenyl 6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-carboxylate

Guidance literature:: With trifluoroacetic acid; In methoxybenzene; at 20 ℃; for 4.5h;

Reference yield:

: 889857-35-6
[((2E)-3-(5-chloro-2-methoxyphenyl)-2-{[(2,4,6-trimethoxybenzyl)amino]methyl}-2-propenyl)amino]ethyl acetate hydrochloride

: 1312770-62-9
(6R)-2-chlorophenyl 6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide; water / methanol / 2 h / 20 °C

2.1: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C

3.1: 2 % platinum on carbon; hydrogen / tetrahydrofuran / 60 h / 20 °C

4.1: CHIRALCEL OD-H / acetonitrile; trifluoroacetic acid / Resolution of racemate

5.1: n-butyllithium / hexane; 1,2-dimethoxyethane / 20 °C

5.2: 1 h / -78 °C

6.1: trifluoroacetic acid; methoxybenzene / 2 h / 20 °C

With n-butyllithium; 2 % platinum on carbon; water; hydrogen; benzotriazol-1-ol; methoxybenzene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; hexane; N,N-dimethyl-formamide; acetonitrile; trifluoroacetic acid;
DOI:10.1016/j.bmc.2013.04.079

Reference yield:

: 889857-36-7
C₂₃H₂₇ClN₂O₇*ClH

: 1312770-62-9
(6R)-2-chlorophenyl 6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C

2.1: 2 % platinum on carbon; hydrogen / tetrahydrofuran / 60 h / 20 °C

3.1: CHIRALCEL OD-H / acetonitrile; trifluoroacetic acid / Resolution of racemate

4.1: n-butyllithium / hexane; 1,2-dimethoxyethane / 20 °C

4.2: 1 h / -78 °C

5.1: trifluoroacetic acid; methoxybenzene / 2 h / 20 °C

With n-butyllithium; 2 % platinum on carbon; hydrogen; benzotriazol-1-ol; methoxybenzene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; hexane; N,N-dimethyl-formamide; acetonitrile; trifluoroacetic acid;
DOI:10.1016/j.bmc.2013.04.079