4-fluoro-2-(2-fluoro-4-iodo-phenylamino)-6-(3-bis-methanesulfonylamino-phenoxy)-benzamide

Base Information

Chemical Name:4-fluoro-2-(2-fluoro-4-iodo-phenylamino)-6-(3-bis-methanesulfonylamino-phenoxy)-benzamide
CAS No.:1084332-49-9
Molecular Formula:C₂₁H₁₈F₂IN₃O₆S₂
Molecular Weight:637.424
Hs Code.:

Synonyms:4-fluoro-2-(2-fluoro-4-iodo-phenylamino)-6-(3-bis-methanesulfonylamino-phenoxy)-benzamide

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Chemical Property of 4-fluoro-2-(2-fluoro-4-iodo-phenylamino)-6-(3-bis-methanesulfonylamino-phenoxy)-benzamide

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Technology Process of 4-fluoro-2-(2-fluoro-4-iodo-phenylamino)-6-(3-bis-methanesulfonylamino-phenoxy)-benzamide

There total 7 articles about 4-fluoro-2-(2-fluoro-4-iodo-phenylamino)-6-(3-bis-methanesulfonylamino-phenoxy)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1084332-21-7
2-(3-amino-phenoxy)-4-fluoro-6-(2-fluoro-4-iodo-phenylamino)-benzamide

: 124-63-0
methanesulfonyl chloride

: 1084332-48-8
4-fluoro-2-(2-fluoro-4-iodo-phenylamino)-6-(3-methanesulfonylamino-phenoxy)-benzamide

: 1084332-49-9
4-fluoro-2-(2-fluoro-4-iodo-phenylamino)-6-(3-bis-methanesulfonylamino-phenoxy)-benzamide

Guidance literature:: 2-(3-amino-phenoxy)-4-fluoro-6-(2-fluoro-4-iodo-phenylamino)-benzamide; With pyridine; In dichloromethane; at 3 ℃; for 0.166667h;

methanesulfonyl chloride; In dichloromethane;

Reference yield:

: 1084331-91-8
{3-[2-cyano-5-fluoro-3-(2-fluoro-4-iodo-phenylamino)-phenoxy]-phenyl}-carbamic acid tert-butyl ester

: 1084332-48-8
4-fluoro-2-(2-fluoro-4-iodo-phenylamino)-6-(3-methanesulfonylamino-phenoxy)-benzamide

: 1084332-49-9
4-fluoro-2-(2-fluoro-4-iodo-phenylamino)-6-(3-bis-methanesulfonylamino-phenoxy)-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / water; dimethyl sulfoxide

1.2: 2.33 h / 63 - 65 °C

2.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

3.1: pyridine / dichloromethane / 0.17 h / 3 °C

With pyridine; sodium hydroxide; trifluoroacetic acid; In dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 1084332-06-8
{3-[2-carbamoyl-5-fluoro-3-(2-fluoro-4-iodo-phenylamino)-phenoxy]-phenyl}-carbamic acid tert-butyl ester

: 1084332-48-8
4-fluoro-2-(2-fluoro-4-iodo-phenylamino)-6-(3-methanesulfonylamino-phenoxy)-benzamide

: 1084332-49-9
4-fluoro-2-(2-fluoro-4-iodo-phenylamino)-6-(3-bis-methanesulfonylamino-phenoxy)-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

2: pyridine / dichloromethane / 0.17 h / 3 °C

With pyridine; trifluoroacetic acid; In dichloromethane;