1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(2H-2-tetrazolyl)phenyl]-2(1H,3H)-imidazolone

Base Information

Chemical Name:1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(2H-2-tetrazolyl)phenyl]-2(1H,3H)-imidazolone
CAS No.:181869-37-4
Molecular Formula:C₂₂H₁₉F₂N₉O₂
Molecular Weight:479.449
Hs Code.:

Synonyms:1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(2H-2-tetrazolyl)phenyl]-2(1H,3H)-imidazolone

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Chemical Property of 1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(2H-2-tetrazolyl)phenyl]-2(1H,3H)-imidazolone

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Technology Process of 1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(2H-2-tetrazolyl)phenyl]-2(1H,3H)-imidazolone

There total 6 articles about 1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(2H-2-tetrazolyl)phenyl]-2(1H,3H)-imidazolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 124627-86-7,132563-70-3,132563-77-0,135270-07-4,135270-10-9,135270-13-2,141611-70-3,127000-90-2
1-(((2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)-methyl)-1H-1,2,4-triazole

: 181870-54-2
1-[4-(2H-2-tetrazolyl)phenyl]-2(1H,3H)-imidazolone

: 181869-37-4
1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(2H-2-tetrazolyl)phenyl]-2(1H,3H)-imidazolone

Guidance literature:: 1-[4-(2H-2-tetrazolyl)phenyl]-2(1H,3H)-imidazolone; With sodium hydride; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 1.5h;

1-(((2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)-methyl)-1H-1,2,4-triazole; In 1-methyl-pyrrolidin-2-one; at 80 ℃; for 19h;
DOI:10.1248/cpb.48.1935

Reference yield:

: 52708-35-7
2-(4-aminophenyl)-2H-tetrazole

: 181869-37-4
1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(2H-2-tetrazolyl)phenyl]-2(1H,3H)-imidazolone

Guidance literature:: Multi-step reaction with 4 steps

1.1: 89 percent / pyridine / CH₂Cl₂ / 0.5 h / 0 °C

2.1: 92 percent / pyridine / 3 h / 50 °C

3.1: 62 percent / aq. HCl / methanol / 14 h / 20 °C

4.1: NaH / 1-methyl-pyrrolidin-2-one / 1.5 h / 20 °C

4.2: 17 percent / 1-methyl-pyrrolidin-2-one / 19 h / 80 °C

With pyridine; hydrogenchloride; sodium hydride; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane;
DOI:10.1248/cpb.48.1935

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 181869-37-4
1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(2H-2-tetrazolyl)phenyl]-2(1H,3H)-imidazolone

Guidance literature:: Multi-step reaction with 5 steps

1.1: K₂CO₃ / dimethylformamide / 10 h / 70 - 75 °C

1.2: 25 percent / N₂H₄*H₂O; FeCl₃; activated carbon / tetrahydrofuran; methanol / 10 h / 50 °C

2.1: 89 percent / pyridine / CH₂Cl₂ / 0.5 h / 0 °C

3.1: 92 percent / pyridine / 3 h / 50 °C

4.1: 62 percent / aq. HCl / methanol / 14 h / 20 °C

5.1: NaH / 1-methyl-pyrrolidin-2-one / 1.5 h / 20 °C

5.2: 17 percent / 1-methyl-pyrrolidin-2-one / 19 h / 80 °C

With pyridine; hydrogenchloride; sodium hydride; potassium carbonate; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.48.1935