{4-[(2R,4S)-5-((3S,5R)-3,5-Dibenzyl-2-oxo-pyrrolidin-1-yl)-4-hydroxy-2-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-pentyl]-phenoxy}-acetic acid methyl ester

Base Information

Chemical Name:{4-[(2R,4S)-5-((3S,5R)-3,5-Dibenzyl-2-oxo-pyrrolidin-1-yl)-4-hydroxy-2-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-pentyl]-phenoxy}-acetic acid methyl ester
CAS No.:852460-12-9
Molecular Formula:C₄₂H₄₆N₂O₇
Molecular Weight:690.836
Hs Code.:

Synonyms:{4-[(2R,4S)-5-((3S,5R)-3,5-Dibenzyl-2-oxo-pyrrolidin-1-yl)-4-hydroxy-2-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-pentyl]-phenoxy}-acetic acid methyl ester

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Chemical Property of {4-[(2R,4S)-5-((3S,5R)-3,5-Dibenzyl-2-oxo-pyrrolidin-1-yl)-4-hydroxy-2-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-pentyl]-phenoxy}-acetic acid methyl ester

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Technology Process of {4-[(2R,4S)-5-((3S,5R)-3,5-Dibenzyl-2-oxo-pyrrolidin-1-yl)-4-hydroxy-2-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-pentyl]-phenoxy}-acetic acid methyl ester

There total 10 articles about {4-[(2R,4S)-5-((3S,5R)-3,5-Dibenzyl-2-oxo-pyrrolidin-1-yl)-4-hydroxy-2-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-pentyl]-phenoxy}-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 96-32-2
bromoacetic acid methyl ester

: (2R,4S)-5-((3S,5R)-3,5-Dibenzyl-2-oxo-pyrrolidin-1-yl)-4-hydroxy-2-(4-hydroxy-benzyl)-pentanoic acid ((1S,2R)-2-hydroxy-indan-1-yl)-amide

: 852460-12-9
{4-[(2R,4S)-5-((3S,5R)-3,5-Dibenzyl-2-oxo-pyrrolidin-1-yl)-4-hydroxy-2-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-pentyl]-phenoxy}-acetic acid methyl ester

Guidance literature:: With caesium carbonate; In 1,4-dioxane; at 80 ℃;
DOI:10.1016/j.bmcl.2004.10.029

Reference yield:

: 72155-45-4
Boc-L-phenylalaninal

: 852460-12-9
{4-[(2R,4S)-5-((3S,5R)-3,5-Dibenzyl-2-oxo-pyrrolidin-1-yl)-4-hydroxy-2-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-pentyl]-phenoxy}-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 77 percent / CHCl₃ / 20 °C

2: 100 percent / H₂ / Pd/C / methanol / 760 Torr

3: TFA / CH₂Cl₂

4: K₂CO₃ / methanol

5: 85 percent / P₄-phosphazene / tetrahydrofuran / -20 °C

6: 93 percent / aq. HCl / propan-2-ol / 20 °C

7: 92 percent / H₂ / Pd(OH)2/C / ethanol

8: 64 percent / Cs₂CO₃ / dioxane / 80 °C

With hydrogenchloride; P₄-phosphazene; hydrogen; potassium carbonate; caesium carbonate; trifluoroacetic acid; palladium dihydroxide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; chloroform; isopropyl alcohol; 1: Wittig reaction;
DOI:10.1016/j.bmcl.2004.10.029

Reference yield:

: 194655-89-5
(3S,5R)-3,5-Dibenzyl-pyrrolidin-2-one

: 852460-12-9
{4-[(2R,4S)-5-((3S,5R)-3,5-Dibenzyl-2-oxo-pyrrolidin-1-yl)-4-hydroxy-2-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-pentyl]-phenoxy}-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / P₄-phosphazene / tetrahydrofuran / -20 °C

2: 93 percent / aq. HCl / propan-2-ol / 20 °C

3: 92 percent / H₂ / Pd(OH)2/C / ethanol

4: 64 percent / Cs₂CO₃ / dioxane / 80 °C

With hydrogenchloride; P₄-phosphazene; hydrogen; caesium carbonate; palladium dihydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; isopropyl alcohol;
DOI:10.1016/j.bmcl.2004.10.029