194655-89-5Relevant articles and documents
Optimization of pyrrolidinone based HIV protease inhibitors
Sherrill, Ronald G.,Andrews, C. Webster,Bock, William J.,Davis-Ward, Ronda G.,Furfine, Eric S.,Hazen, Richard J.,Rutkowske, Randy D.,Spaltenstein, Andrew,Wright, Lois L.
, p. 81 - 84 (2007/10/03)
The synthesis and enhanced antiviral activity of a series of P1′-optimized 3,5-dibenzyl pyrrolidinone based HIV protease inhibitors is described. Optimization of P1-substituted pyrrolidinone based HIV protease inhibitors has yielded analogs with very pote
Design and synthesis of novel conformationally restricted HIV protease inhibitors
Salituro, Francesco G.,Baker, Christopher T.,Court, John J.,Deininger, David D.,Kim, Eunice E.,Li, Biquin,Novak, Perry M.,Rao, Bhisetti G.,Pazhanisamy,Porter, Margaret D.,Schairer, Wayne C.,Tung, Roger D.
, p. 3637 - 3642 (2007/10/03)
A set of HIV protease inhibitors represented by compound 2 has previously been described. Structural and conformational analysis of this compound suggested that conformational restriction of the P1/P2 portion of the molecule could lead to a novel set of potent protease inhibitors. Thus, probe compounds 3-7 were designed, synthesized, and found to be potent inhibitors of HIV protease.