N-[2-(tert-butyl(dimethyl)silyloxy)-5-(9-phenylxanthen-9-yloxy)cyclopentyl]-2-(thymin-1-yl)acetamide

Base Information

Chemical Name:N-[2-(tert-butyl(dimethyl)silyloxy)-5-(9-phenylxanthen-9-yloxy)cyclopentyl]-2-(thymin-1-yl)acetamide
CAS No.:611183-03-0
Molecular Formula:C₃₇H₄₃N₃O₆Si
Molecular Weight:653.85
Hs Code.:

Synonyms:N-[2-(tert-butyl(dimethyl)silyloxy)-5-(9-phenylxanthen-9-yloxy)cyclopentyl]-2-(thymin-1-yl)acetamide

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Chemical Property of N-[2-(tert-butyl(dimethyl)silyloxy)-5-(9-phenylxanthen-9-yloxy)cyclopentyl]-2-(thymin-1-yl)acetamide

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Technology Process of N-[2-(tert-butyl(dimethyl)silyloxy)-5-(9-phenylxanthen-9-yloxy)cyclopentyl]-2-(thymin-1-yl)acetamide

There total 12 articles about N-[2-(tert-butyl(dimethyl)silyloxy)-5-(9-phenylxanthen-9-yloxy)cyclopentyl]-2-(thymin-1-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 68845-73-8
tert-butyl(cyclopent-2-en-1-yloxy)dimethylsilane

: 611183-03-0
N-[2-(tert-butyl(dimethyl)silyloxy)-5-(9-phenylxanthen-9-yloxy)cyclopentyl]-2-(thymin-1-yl)acetamide

Guidance literature:: Multi-step reaction with 11 steps

1: 42 percent / m-CPBA / CH₂Cl₂ / 20 °C

2: 93 percent / Bu₄NF*3H₂O / tetrahydrofuran / 20 °C

3: 79 percent / toluene / 95 °C

4: 76 percent / NaH / dimethylformamide / 20 °C

5: 97 percent / pyridine; DMAP / 6 h / 20 °C

6: 31 percent / pig liver esterase; phosphate buffer / H₂O / pH 7

7: 82 percent / KOH / ethanol / Heating

8: 98 percent / H₂ / Pd/C / ethanol / 20 h / 20 °C / 7600 Torr

9: 65 percent / EDC / dimethylformamide / 20 °C

10: 52 mg / pyridine / dimethylsulfoxide / 20 h / 20 °C

11: imidazole / dimethylformamide / 20 °C

With pyridine; 1H-imidazole; dmap; potassium hydroxide; phosphate buffer; pig liver esterase; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo034143q

Reference yield:

: 34310-95-7
trans-6-oxabicyclo<3.1.0>hexan-2-ol

: 611183-03-0
N-[2-(tert-butyl(dimethyl)silyloxy)-5-(9-phenylxanthen-9-yloxy)cyclopentyl]-2-(thymin-1-yl)acetamide

Guidance literature:: Multi-step reaction with 9 steps

1: 79 percent / toluene / 95 °C

2: 76 percent / NaH / dimethylformamide / 20 °C

3: 97 percent / pyridine; DMAP / 6 h / 20 °C

4: 31 percent / pig liver esterase; phosphate buffer / H₂O / pH 7

5: 82 percent / KOH / ethanol / Heating

6: 98 percent / H₂ / Pd/C / ethanol / 20 h / 20 °C / 7600 Torr

7: 65 percent / EDC / dimethylformamide / 20 °C

8: 52 mg / pyridine / dimethylsulfoxide / 20 h / 20 °C

9: imidazole / dimethylformamide / 20 °C

With pyridine; 1H-imidazole; dmap; potassium hydroxide; phosphate buffer; pig liver esterase; hydrogen; sodium hydride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo034143q

Reference yield:

: (1α,2β,5α)-2-(tert-butyldimethylsilyloxy)-6-oxabicyclo<3.1.0>hexane

: 611183-03-0
N-[2-(tert-butyl(dimethyl)silyloxy)-5-(9-phenylxanthen-9-yloxy)cyclopentyl]-2-(thymin-1-yl)acetamide

Guidance literature:: Multi-step reaction with 10 steps

1: 93 percent / Bu₄NF*3H₂O / tetrahydrofuran / 20 °C

2: 79 percent / toluene / 95 °C

3: 76 percent / NaH / dimethylformamide / 20 °C

4: 97 percent / pyridine; DMAP / 6 h / 20 °C

5: 31 percent / pig liver esterase; phosphate buffer / H₂O / pH 7

6: 82 percent / KOH / ethanol / Heating

7: 98 percent / H₂ / Pd/C / ethanol / 20 h / 20 °C / 7600 Torr

8: 65 percent / EDC / dimethylformamide / 20 °C

9: 52 mg / pyridine / dimethylsulfoxide / 20 h / 20 °C

10: imidazole / dimethylformamide / 20 °C

With pyridine; 1H-imidazole; dmap; potassium hydroxide; phosphate buffer; pig liver esterase; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo034143q