3,4-diamino-6-(4-ethoxy-3-trifluoromethyl-phenyl)-pyridine-2-carbonitrile

Base Information

• Chemical Name: 3,4-diamino-6-(4-ethoxy-3-trifluoromethyl-phenyl)-pyridine-2-carbonitrile
• CAS No.: 944388-73-2
• Molecular Formula: C₁₅H₁₃F₃N₄O
• Molecular Weight: 322.29

Synonyms:3,4-diamino-6-(4-ethoxy-3-trifluoromethyl-phenyl)-pyridine-2-carbonitrile

Chemical Property of 3,4-diamino-6-(4-ethoxy-3-trifluoromethyl-phenyl)-pyridine-2-carbonitrile

Chemical Property:

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Technology Process of 3,4-diamino-6-(4-ethoxy-3-trifluoromethyl-phenyl)-pyridine-2-carbonitrile

There total 1 articles about 3,4-diamino-6-(4-ethoxy-3-trifluoromethyl-phenyl)-pyridine-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-amino-6-(4-ethoxy-3-trifluoromethyl-phenyl)-3-nitro-pyridine-2-carbonitrile (944388-72-1) → 3,4-diamino-6-(4-ethoxy-3-trifluoromethyl-phenyl)-pyridine-2-carbonitrile (944388-73-2)

Guidance literature:

With 10% palladium on carbon; hydrogen; In ethyl acetate; for 1h;

DOI:10.1016/j.bmcl.2010.06.072

Reference yield:

3,4-diamino-6-(4-ethoxy-3-trifluoromethyl-phenyl)-pyridine-2-carbonitrile (944388-73-2) + 2-chloro-1,1,1-triethoxyethane (51076-95-0) → 6-(4-ethoxy-3-trifluoromethyl-phenyl)-2-(chloromethyl)-1H-imidazo[4,5-c]pyridine-4-carbonitrile (944388-74-3)

Guidance literature:

ytterbium(III) triflate; In acetonitrile; Product distribution / selectivity; Heating/reflux;

Reference yield:

3,4-diamino-6-(4-ethoxy-3-trifluoromethyl-phenyl)-pyridine-2-carbonitrile (944388-73-2) + orthoformic acid triethyl ester (122-51-0) → 6-(4-ethoxy-3-trifluoromethyl-phenyl)-1H-imidazo[4,5-c]pyridine-4-carbonitrile (944387-66-0)

Guidance literature:

With ytterbium(III) triflate; In acetonitrile; at 90 ℃; for 0.5h;

DOI:10.1016/j.bmcl.2010.06.072

upstream raw materials:

4-amino-6-(4-ethoxy-3-trifluoromethyl-phenyl)-3-nitro-pyridine-2-carbonitrile

Downstream raw materials:

6-(4-ethoxy-3-trifluoromethyl-phenyl)-2-(chloromethyl)-1H-imidazo[4,5-c]pyridine-4-carbonitrile

6-(4-ethoxy-3-trifluoromethyl-phenyl)-1H-imidazo[4,5-c]pyridine-4-carbonitrile

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